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A9IYY8 (SYL_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BT_2478
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length886 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 886886Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334731

Regions

Motif51 – 6111"HIGH" region HAMAP-Rule MF_00049
Motif644 – 6485"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6471ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9IYY8 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 2065F8563BD3CE81

FASTA886100,111
        10         20         30         40         50         60 
MGMTIEHYKI GERYNPRARE KKWQEIWDEK KIFQTVQGDG REKYYVLEMF PYPSGRIHMG 

        70         80         90        100        110        120 
HVRNYAMGDV VARYKRAKGF NVLHPMGWDA FGMPAENAAL QSKVHPKTWT YENIAVMRGQ 

       130        140        150        160        170        180 
LKQLGLSLDW AREFATCDVD YYHRQQMLFL DFYQKGLVAR KVAKVNWDPV DHTVLANEQV 

       190        200        210        220        230        240 
VDGRGWRSGA LVEQRELTQW FFKISDFSED LLAGLEELDQ WPEKVRTMQK NWIGKSQGLL 

       250        260        270        280        290        300 
IRWALKSTAD DAGGSNDVCE AFDEVVCYST RPDTLFGASF LALSVDHPIA QSLAKKDKAL 

       310        320        330        340        350        360 
AAFIENCRCG GTTTAALETA EKQGFLTPLV AVHPFDETVH IPVYIANFVL MDYGTGAIFG 

       370        380        390        400        410        420 
CPAHDQRDFD FARKYDLPIK PVVLPRETKV EDFVLAEMPY TGDGVMINSS FLDGLTPQQA 

       430        440        450        460        470        480 
FEEVAKRLEQ QVLHGQPQGK KTVQFRLRDW GISRQRYWGC PIPMIHCTSC GVVPVPRADL 

       490        500        510        520        530        540 
PVVLPDDVTF DQPGNPLARH EMWQDVACPI CGQPAKRETD TMDTFVDSSW YYARFTAPFA 

       550        560        570        580        590        600 
PEPVEKQATA EWLPVQQYIG GIEHAILHLL YARFFMRAMK LVGHVSVDEP FKGLFTQGMV 

       610        620        630        640        650        660 
VHETYRDDQG WVSPAEISIV EKDGKRCAYK LTDQSEVTIG LIEKMSKSKK NVVDPDDIIA 

       670        680        690        700        710        720 
SYGADTVRWF VLSDSPPERD VIWTESGVEG AHRFVQRVWR HVALSAAVLK DVAPRAGHQG 

       730        740        750        760        770        780 
AALELSKAAH RMLHAVEDDL EKFAFNRAIA RLYEFLNIMA PLLNKVADVE DEMKAALRQA 

       790        800        810        820        830        840 
MDFFLAMIAP IMPHLAEECH AALGETTLMS ELAWPVYDPA LIVEESYTLP VQINGKKRGE 

       850        860        870        880 
VTVAATASET MIKEAVLALD FVQAQLVEKP MKKIIIVPQR IVNVVL 

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260525 Genomic DNA. Translation: CAK02453.1.
RefSeqYP_001610448.1. NC_010161.1.

3D structure databases

ProteinModelPortalA9IYY8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382640.Btr_2478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5830289.
KEGGbtr:Btr_2478.
PATRIC20552796. VBIBarTri113218_2515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBTRI382640:GJEK-1962-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BART1
AccessionPrimary (citable) accession number: A9IYY8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries