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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei647ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BT_2478
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347311 – 886Leucine--tRNA ligaseAdd BLAST886

Proteomic databases

PRIDEiA9IYY8

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_2478

Structurei

3D structure databases

ProteinModelPortaliA9IYY8
SMRiA9IYY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi644 – 648"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9IYY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMTIEHYKI GERYNPRARE KKWQEIWDEK KIFQTVQGDG REKYYVLEMF
60 70 80 90 100
PYPSGRIHMG HVRNYAMGDV VARYKRAKGF NVLHPMGWDA FGMPAENAAL
110 120 130 140 150
QSKVHPKTWT YENIAVMRGQ LKQLGLSLDW AREFATCDVD YYHRQQMLFL
160 170 180 190 200
DFYQKGLVAR KVAKVNWDPV DHTVLANEQV VDGRGWRSGA LVEQRELTQW
210 220 230 240 250
FFKISDFSED LLAGLEELDQ WPEKVRTMQK NWIGKSQGLL IRWALKSTAD
260 270 280 290 300
DAGGSNDVCE AFDEVVCYST RPDTLFGASF LALSVDHPIA QSLAKKDKAL
310 320 330 340 350
AAFIENCRCG GTTTAALETA EKQGFLTPLV AVHPFDETVH IPVYIANFVL
360 370 380 390 400
MDYGTGAIFG CPAHDQRDFD FARKYDLPIK PVVLPRETKV EDFVLAEMPY
410 420 430 440 450
TGDGVMINSS FLDGLTPQQA FEEVAKRLEQ QVLHGQPQGK KTVQFRLRDW
460 470 480 490 500
GISRQRYWGC PIPMIHCTSC GVVPVPRADL PVVLPDDVTF DQPGNPLARH
510 520 530 540 550
EMWQDVACPI CGQPAKRETD TMDTFVDSSW YYARFTAPFA PEPVEKQATA
560 570 580 590 600
EWLPVQQYIG GIEHAILHLL YARFFMRAMK LVGHVSVDEP FKGLFTQGMV
610 620 630 640 650
VHETYRDDQG WVSPAEISIV EKDGKRCAYK LTDQSEVTIG LIEKMSKSKK
660 670 680 690 700
NVVDPDDIIA SYGADTVRWF VLSDSPPERD VIWTESGVEG AHRFVQRVWR
710 720 730 740 750
HVALSAAVLK DVAPRAGHQG AALELSKAAH RMLHAVEDDL EKFAFNRAIA
760 770 780 790 800
RLYEFLNIMA PLLNKVADVE DEMKAALRQA MDFFLAMIAP IMPHLAEECH
810 820 830 840 850
AALGETTLMS ELAWPVYDPA LIVEESYTLP VQINGKKRGE VTVAATASET
860 870 880
MIKEAVLALD FVQAQLVEKP MKKIIIVPQR IVNVVL
Length:886
Mass (Da):100,111
Last modified:February 5, 2008 - v1
Checksum:i2065F8563BD3CE81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA Translation: CAK02453.1

Genome annotation databases

KEGGibtr:BT_2478

Similar proteinsi

Entry informationi

Entry nameiSYL_BART1
AccessioniPrimary (citable) accession number: A9IYY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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