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A9IYY8

- SYL_BART1

UniProt

A9IYY8 - SYL_BART1

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Protein

Leucine--tRNA ligase

Gene
leuS, BT_2478
Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-1962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BT_2478
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Leucine--tRNA ligaseUniRule annotationPRO_0000334731Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_2478.

Structurei

3D structure databases

ProteinModelPortaliA9IYY8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionUniRule annotationAdd
BLAST
Motifi644 – 6485"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9IYY8-1 [UniParc]FASTAAdd to Basket

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MGMTIEHYKI GERYNPRARE KKWQEIWDEK KIFQTVQGDG REKYYVLEMF    50
PYPSGRIHMG HVRNYAMGDV VARYKRAKGF NVLHPMGWDA FGMPAENAAL 100
QSKVHPKTWT YENIAVMRGQ LKQLGLSLDW AREFATCDVD YYHRQQMLFL 150
DFYQKGLVAR KVAKVNWDPV DHTVLANEQV VDGRGWRSGA LVEQRELTQW 200
FFKISDFSED LLAGLEELDQ WPEKVRTMQK NWIGKSQGLL IRWALKSTAD 250
DAGGSNDVCE AFDEVVCYST RPDTLFGASF LALSVDHPIA QSLAKKDKAL 300
AAFIENCRCG GTTTAALETA EKQGFLTPLV AVHPFDETVH IPVYIANFVL 350
MDYGTGAIFG CPAHDQRDFD FARKYDLPIK PVVLPRETKV EDFVLAEMPY 400
TGDGVMINSS FLDGLTPQQA FEEVAKRLEQ QVLHGQPQGK KTVQFRLRDW 450
GISRQRYWGC PIPMIHCTSC GVVPVPRADL PVVLPDDVTF DQPGNPLARH 500
EMWQDVACPI CGQPAKRETD TMDTFVDSSW YYARFTAPFA PEPVEKQATA 550
EWLPVQQYIG GIEHAILHLL YARFFMRAMK LVGHVSVDEP FKGLFTQGMV 600
VHETYRDDQG WVSPAEISIV EKDGKRCAYK LTDQSEVTIG LIEKMSKSKK 650
NVVDPDDIIA SYGADTVRWF VLSDSPPERD VIWTESGVEG AHRFVQRVWR 700
HVALSAAVLK DVAPRAGHQG AALELSKAAH RMLHAVEDDL EKFAFNRAIA 750
RLYEFLNIMA PLLNKVADVE DEMKAALRQA MDFFLAMIAP IMPHLAEECH 800
AALGETTLMS ELAWPVYDPA LIVEESYTLP VQINGKKRGE VTVAATASET 850
MIKEAVLALD FVQAQLVEKP MKKIIIVPQR IVNVVL 886
Length:886
Mass (Da):100,111
Last modified:February 5, 2008 - v1
Checksum:i2065F8563BD3CE81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK02453.1.
RefSeqiYP_001610448.1. NC_010161.1.

Genome annotation databases

GeneIDi5830289.
KEGGibtr:Btr_2478.
PATRICi20552796. VBIBarTri113218_2515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK02453.1 .
RefSeqi YP_001610448.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9IYY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_2478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5830289.
KEGGi btr:Btr_2478.
PATRICi 20552796. VBIBarTri113218_2515.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BTRI382640:GJEK-1962-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiSYL_BART1
AccessioniPrimary (citable) accession number: A9IYY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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