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A9IYY8

- SYL_BART1

UniProt

A9IYY8 - SYL_BART1

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei647 – 6471ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBTRI382640:GJEK-1962-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BT_2478
    OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
    Taxonomic identifieri382640 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000001592: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Leucine--tRNA ligasePRO_0000334731Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382640.Btr_2478.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IYY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi644 – 6485"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9IYY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMTIEHYKI GERYNPRARE KKWQEIWDEK KIFQTVQGDG REKYYVLEMF    50
    PYPSGRIHMG HVRNYAMGDV VARYKRAKGF NVLHPMGWDA FGMPAENAAL 100
    QSKVHPKTWT YENIAVMRGQ LKQLGLSLDW AREFATCDVD YYHRQQMLFL 150
    DFYQKGLVAR KVAKVNWDPV DHTVLANEQV VDGRGWRSGA LVEQRELTQW 200
    FFKISDFSED LLAGLEELDQ WPEKVRTMQK NWIGKSQGLL IRWALKSTAD 250
    DAGGSNDVCE AFDEVVCYST RPDTLFGASF LALSVDHPIA QSLAKKDKAL 300
    AAFIENCRCG GTTTAALETA EKQGFLTPLV AVHPFDETVH IPVYIANFVL 350
    MDYGTGAIFG CPAHDQRDFD FARKYDLPIK PVVLPRETKV EDFVLAEMPY 400
    TGDGVMINSS FLDGLTPQQA FEEVAKRLEQ QVLHGQPQGK KTVQFRLRDW 450
    GISRQRYWGC PIPMIHCTSC GVVPVPRADL PVVLPDDVTF DQPGNPLARH 500
    EMWQDVACPI CGQPAKRETD TMDTFVDSSW YYARFTAPFA PEPVEKQATA 550
    EWLPVQQYIG GIEHAILHLL YARFFMRAMK LVGHVSVDEP FKGLFTQGMV 600
    VHETYRDDQG WVSPAEISIV EKDGKRCAYK LTDQSEVTIG LIEKMSKSKK 650
    NVVDPDDIIA SYGADTVRWF VLSDSPPERD VIWTESGVEG AHRFVQRVWR 700
    HVALSAAVLK DVAPRAGHQG AALELSKAAH RMLHAVEDDL EKFAFNRAIA 750
    RLYEFLNIMA PLLNKVADVE DEMKAALRQA MDFFLAMIAP IMPHLAEECH 800
    AALGETTLMS ELAWPVYDPA LIVEESYTLP VQINGKKRGE VTVAATASET 850
    MIKEAVLALD FVQAQLVEKP MKKIIIVPQR IVNVVL 886
    Length:886
    Mass (Da):100,111
    Last modified:February 5, 2008 - v1
    Checksum:i2065F8563BD3CE81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK02453.1.
    RefSeqiYP_001610448.1. NC_010161.1.

    Genome annotation databases

    GeneIDi5830289.
    KEGGibtr:Btr_2478.
    PATRICi20552796. VBIBarTri113218_2515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK02453.1 .
    RefSeqi YP_001610448.1. NC_010161.1.

    3D structure databases

    ProteinModelPortali A9IYY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382640.Btr_2478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5830289.
    KEGGi btr:Btr_2478.
    PATRICi 20552796. VBIBarTri113218_2515.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BTRI382640:GJEK-1962-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
      Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
      Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIP 105476 / IBS 506.

    Entry informationi

    Entry nameiSYL_BART1
    AccessioniPrimary (citable) accession number: A9IYY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3