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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei208ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi21 – 22ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi217 – 221ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotationImported
Ordered Locus Names:BT_1714Imported
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)Imported
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi382640.Btr_1714

Structurei

3D structure databases

ProteinModelPortaliA9IWQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 22"HIGH" regionUniRule annotation9
Motifi217 – 221"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.6202 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9IWQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTFTPLVFS GVQPSGHLHL GNYLGALQHW VELQNSHHCL YCVVDMHALT
60 70 80 90 100
VNPDPLILRE STRTVTAAFL AAGIDPQKHI IFNQSRVFQH AELAWIFNCV
110 120 130 140 150
ARIGWLQRMT QFKDKAGKDR EKASLGLFAY PTLMAADILV YRATHVPVGE
160 170 180 190 200
DQKQHVELTR DIAQKFNNDY AQRIADLNFG VSMQTDEEKR QGFFPLPEAL
210 220 230 240 250
IGTTATRVMS LRDGTKKMSK SDPSDFSRIN LTDDADLIAK KIRKAKTDSA
260 270 280 290 300
PLPDTLAALK ERPEVDNLLG IYAAFAKVSK EKVLLEFSGH QFSHFKTALA
310 320 330 340 350
DLAVHKLAPI TEELRRLHQE SGYIDSVLHD GAKRASMLAE ENMKKIREIV

GFLLNT
Length:356
Mass (Da):39,962
Last modified:February 5, 2008 - v1
Checksum:i01C6EEB5F4A24FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA Translation: CAK02023.1
RefSeqiWP_012232135.1, NC_010161.1

Genome annotation databases

KEGGibtr:BT_1714

Similar proteinsi

Entry informationi

Entry nameiA9IWQ8_BART1
AccessioniPrimary (citable) accession number: A9IWQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported