A9IWF5 (UBIC_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	BT_1627

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.
Sequence caution	The sequence CAK01961.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000335806
Sites
	Binding site	36	1	Substrate; via amide nitrogen By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IWF5 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 3C625B82FC5DBCDD	FASTA	169	20,158
	10 20 30 40 50 60 MSDLEDSILP PLKWLFDQNP PIPENIRDWL MESGSMTLRL KKYCTCFQVQ RQRECFIMRD 70 80 90 100 110 120 KLKEEAEHLP KSARYWLREV ILMGDNKPWL LGRTVIPQET LLHNQSLMHL GTTPLGHYLF 130 140 150 160 NNDKLTRDYI HIGQQGVLWA RRSRLRLRDK PLLLTELFLP DSPLYLHHK

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK01961.1. Different initiation.
RefSeq	YP_001609956.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IWF5.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IWF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5830644.
GenomeReviews	Gene locus BT_1627 in contig AM260525_GR.
PATRIC	20551088. VBIBarTri113218_1679.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644467.
ProtClustDB	PRK11655.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_1627-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_BART1

Accession

Primary (citable) accession number: A9IWF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program