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A9IWA8 (MRAY_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BT_1594
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000074533

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane333 – 35321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9IWA8 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: AA70A81C248BEB2B

FASTA35638,681
        10         20         30         40         50         60 
MMLFFSSFSD WFPGVNVFRY ITFRTIAAML TSGLIVFLFG PSIIASLKLR QGKGQPIRAD 

        70         80         90        100        110        120 
GPQTHFKKAG TPTMGGLMIL TGIVVSAFLW CNLSNIYFWV SLLVMLSFGA IGFYDDYLKV 

       130        140        150        160        170        180 
TKQTDKGFSG KARLSLEFFV AAIAAFIILQ IGSSGFALPF LKDYLIHLGW FFIPFSAFVI 

       190        200        210        220        230        240 
VATGNAVNLT DGLDGLAIVP VMVAALSFAL IAYLCGNMNF ADYLQIHYVS GTGELAVLLG 

       250        260        270        280        290        300 
AVVGAGLGFL WFNAPPAAIF MGDTGSLALG GLLGTVAVAT KHEIVLVLIG GLFVVEAFSV 

       310        320        330        340        350 
VIQVGYFKLT RKRVFLMAPI HHHFEKKGWT ESQVVIRFWI ISIVLALIGL STLKLR

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260525 Genomic DNA. Translation: CAK01933.1.
RefSeqYP_001609928.1. NC_010161.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA9IWA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5830083.
GenomeReviewsGene locus BT_1594 in contig AM260525_GR.
PATRIC20551014. VBIBarTri113218_1643.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBTRI382640:BT_1594-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BART1
AccessionPrimary (citable) accession number: A9IWA8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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