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A9IWA5 (MURG_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BT_1591
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000074447

Sequences

Sequence LengthMass (Da)Tools
A9IWA5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 2C2E7EADD69CE08E

FASTA37841,184
        10         20         30         40         50         60 
MNDKKVIVLA AGGTGGHLFP AEALAVELRQ RGYDVHLITD ERARSFVRRF DEEHTHIVSS 

        70         80         90        100        110        120 
ATFTRCHPFA LIKTILSLLK GMGQSLRLFY KLRPVLVGGF GGYPSFPPLF IAVLMRRVTF 

       130        140        150        160        170        180 
IHEQNAVMGR ANRVLAIFVR AIAGGLLSPK GAYAHKTLLT GNPVREAVLK AAEIPYHSPV 

       190        200        210        220        230        240 
GEEPFNFLVF GGSQGASFFS HIVPEAVALL DDQNRKRLRI VQQVRGDAAG LIKIYRDMGV 

       250        260        270        280        290        300 
QAEVAPFFDD MAERMAHAHF ILSRAGASSV CEIAVIGRPA LLIPYPYALD YDQAENAALL 

       310        320        330        340        350        360 
ARVGGAQIIS EKDLSAQKLA ALLTQACCAP HLLEKQALAA KKVGQPYATR CLADMAEALI 

       370 
AGRLLSDIKE ELFDENAT

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260525 Genomic DNA. Translation: CAK01930.1.
RefSeqYP_001609925.1. NC_010161.1.

3D structure databases

ProteinModelPortalA9IWA5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9IWA5.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5829024.
GenomeReviewsGene locus BT_1591 in contig AM260525_GR.
PATRIC20551008. VBIBarTri113218_1640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBTRI382640:BT_1591-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BART1
AccessionPrimary (citable) accession number: A9IWA5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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