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A9IWA4 (MURC_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:BT_1590
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000336815

Regions

Nucleotide binding114 – 1207ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A9IWA4 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 9E3663B2FDD329D1

FASTA47552,282
        10         20         30         40         50         60 
MKMPLDIGVI HFIGIGGIGM SGIAEVFYNL GYKVQGSDQV ESANVERLRR KGINVHIGHY 

        70         80         90        100        110        120 
AENLGNAEVV VFSTAVKKTN PEYIAAKERH LPLVRRAEML AELMRFRRAI AVGGTHGKTT 

       130        140        150        160        170        180 
TTSMVAALLD AGHFDPVVIN GGIINAYGTN SRTGEGDWMI VEADESDGTF LKLPADIAVV 

       190        200        210        220        230        240 
TNIDAEHLDH YGSFDAVRTA FRQFVENVPF YGFAVLCVDH PEVQSLAGRI DDRWVITYGA 

       250        260        270        280        290        300 
NPQADVRFLN LSRDGQKTHF DVLVRSRKTG RKIELKNLLL PMAGQHNVAN ATAAIAIAHE 

       310        320        330        340        350        360 
LGISNELIKK GLAEFGGVKR RFTRTGSWRG IEIFDDYGHH PVEIKAVLRA ARESAKGRVI 

       370        380        390        400        410        420 
AIAQPHRYSR LYHLFDDFAA CFNDADTVLI TPVYAAGEEP IVGFGSQELV EHIKMAGHRD 

       430        440        450        460        470 
VRLIHDLEDV VSLVSKFAQA EDYVVFLGAG NITQWACALP HRLSGLDGYD KFSAH

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM260525 Genomic DNA. Translation: CAK01929.1.
RefSeqYP_001609924.1. NC_010161.1.

3D structure databases

ProteinModelPortalA9IWA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9IWA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5829023.
GenomeReviewsGene locus BT_1590 in contig AM260525_GR.
PATRIC20551006. VBIBarTri113218_1639.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG476594.
OMAYQPHRYS.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycBTRI382640:BT_1590-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BART1
AccessionPrimary (citable) accession number: A9IWA4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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