ID   PUR7_BART1              Reviewed;         254 AA.
AC   A9IVH1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   16-JUN-2009, entry version 12.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=BT_1350;
OS   Bartonella tribocorum (strain CIP 105476 / IBS 506).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=382640;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18037886; DOI=10.1038/ng.2007.38;
RA   Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G.,
RA   Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
RT   "Genomic analysis of Bartonella identifies type IV secretion systems
RT   as host adaptability factors.";
RL   Nat. Genet. 39:1469-1476(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
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DR   EMBL; AM260525; CAK01712.1; -; Genomic_DNA.
DR   RefSeq; YP_001609707.1; -.
DR   GeneID; 5829879; -.
DR   GenomeReviews; AM260525_GR; BT_1350.
DR   OMA; A9IVH1; TAFNAQK.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxam...; IEA:HAMAP.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00137; -; 1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR001636; SAICAR_synt.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   PANTHER; PTHR11609; SAICAR_synt; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   ProDom; PD003043; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   CHAIN         1    254       Phosphoribosylaminoimidazole-
FT                                succinocarboxamide synthase.
FT                                /FTId=PRO_1000076445.
SQ   SEQUENCE   254 AA;  29181 MW;  761AB56EA8403745 CRC64;
     MNRRHRIYEG KAKILYEGPE PGTYIQFFKD DATAFNAKKH EIIDGKGVLN NRISEHIFSH
     LGRLGIPTHF IKRINMREQL IKAVEIIPLE VVVRNVAAGS LAKRLGLEEG APLPQSIIEF
     YYKNDSLDDP MVTEEHITAF GWAVPQEIED IMQLSIRIND FLSGLFAGVN IQLIDFKMEF
     GRLWEDETMR IVLADEISPD SARLWDMQTR EKMDKDRFRR DMGGLINAYQ EVAKRLGIMN
     ENEPIRPSGP VLVK
//