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A9IVF6

- PUR5_BART1

UniProt

A9IVF6 - PUR5_BART1

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBTRI382640:GJEK-1211-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BT_1341
    OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
    Taxonomic identifieri382640 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000001592: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000083450Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382640.Btr_1341.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IVF6.
    SMRiA9IVF6. Positions 55-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000153773.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9IVF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNQDLINNK SKAGLTYAKA GVNIDMGNAM VEKIKPFIRA TKRAGADAEI    50
    GGFGGLFDLK AAGFTDPILV AANDGVGTKL KIAIEVGHHN TVGIDLVAMC 100
    VNDLLVQGAE PLFFLDYFAT GKLDPEQGAA IVSGIAEGCK QSGAALIGGE 150
    TAEMPGMYAE GDYDLAGFAV GACERSMLLP SKNLTEGDII LGLSASGIHS 200
    NGFSLVRRII EQNDLKWNDP APFDPSNNLG VALLTPTRIY VKSLLPIMRK 250
    YEGVKALAHI TGGGFLENIP RVIPSSLCAE INLSTINVPS VFSWIAKQGK 300
    IEETEMLRTF NCGIGMIIIV GQHTAEAVTQ ALEKNGETVT PLGILTKRQD 350
    QNKGILYRGV LHL 363
    Length:363
    Mass (Da):38,539
    Last modified:February 5, 2008 - v1
    Checksum:i215D535BE70E7D3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK01703.1.
    RefSeqiYP_001609698.1. NC_010161.1.

    Genome annotation databases

    GeneIDi5830178.
    KEGGibtr:Btr_1341.
    PATRICi20550479. VBIBarTri113218_1381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260525 Genomic DNA. Translation: CAK01703.1 .
    RefSeqi YP_001609698.1. NC_010161.1.

    3D structure databases

    ProteinModelPortali A9IVF6.
    SMRi A9IVF6. Positions 55-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382640.Btr_1341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5830178.
    KEGGi btr:Btr_1341.
    PATRICi 20550479. VBIBarTri113218_1381.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000153773.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BTRI382640:GJEK-1211-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
      Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
      Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIP 105476 / IBS 506.

    Entry informationi

    Entry nameiPUR5_BART1
    AccessioniPrimary (citable) accession number: A9IVF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3