A9IVF6 (PUR5_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	BT_1341

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_B
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_B.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_B		PRO_1000083450

Sequences

	Sequence		Length	Mass (Da)
	A9IVF6 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 215D535BE70E7D3A	FASTA	363	38,539
	10 20 30 40 50 60 MSNQDLINNK SKAGLTYAKA GVNIDMGNAM VEKIKPFIRA TKRAGADAEI GGFGGLFDLK 70 80 90 100 110 120 AAGFTDPILV AANDGVGTKL KIAIEVGHHN TVGIDLVAMC VNDLLVQGAE PLFFLDYFAT 130 140 150 160 170 180 GKLDPEQGAA IVSGIAEGCK QSGAALIGGE TAEMPGMYAE GDYDLAGFAV GACERSMLLP 190 200 210 220 230 240 SKNLTEGDII LGLSASGIHS NGFSLVRRII EQNDLKWNDP APFDPSNNLG VALLTPTRIY 250 260 270 280 290 300 VKSLLPIMRK YEGVKALAHI TGGGFLENIP RVIPSSLCAE INLSTINVPS VFSWIAKQGK 310 320 330 340 350 360 IEETEMLRTF NCGIGMIIIV GQHTAEAVTQ ALEKNGETVT PLGILTKRQD QNKGILYRGV LHL

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK01703.1.
RefSeq	YP_001609698.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IVF6.
SMR	A9IVF6. Positions 55-347.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IVF6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5830178.
GenomeReviews	Gene locus BT_1341 in contig AM260525_GR.
PATRIC	20550479. VBIBarTri113218_1381.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_1341-MONOMER.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_BART1

Accession

Primary (citable) accession number: A9IVF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program