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A9IU63 (ALR_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:Bpet3162
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Alanine racemase HAMAP-Rule MF_01201
PRO_1000138582

Sites

Active site441Proton acceptor; specific for D-alanine By similarity
Active site2711Proton acceptor; specific for L-alanine By similarity
Binding site1391Substrate By similarity
Binding site3191Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue441N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A9IU63 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 548CEC69C2969A7E

FASTA37639,291
        10         20         30         40         50         60 
MPRPIHASIS LAALAHNLDV VRRHLDQAAQ AAGGAPPSIW AVIKANAYGH GIEAAVAGFS 

        70         80         90        100        110        120 
AAQGLAMLDL AEAVRCREAG WGGPILLLEG FFQPADLDLI DRYHLSATVH TREQLDMLAQ 

       130        140        150        160        170        180 
ARLSRRVDIM LKLNSGMNRL GFDPDAYGSA HARALQLREQ GVVGAVGRMT HFACADGTPG 

       190        200        210        220        230        240 
VAGQLRVFQS VTQGLADGPV SVCNSAATLR YPEIAVAHGA QAHWVRPGIC LYGASPFADA 

       250        260        270        280        290        300 
DAASFGLRPA MSLRSQIIGV QDLPAGAEVG YGATFRAERP MRVGVVACGY ADGYPRHAGT 

       310        320        330        340        350        360 
GTPVVVGGVR TRLVGRVSMD MLMVDLDPVP AAGIGTPVSL WGQDGPSVDE VAQAAGTIGY 

       370 
ELLCALAPRV PVKRDS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP43504.1.
RefSeqYP_001631772.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9IU63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet3162.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP43504; CAP43504; Bpet3162.
GeneID5820170.
KEGGbpt:Bpet3162.
PATRIC21167883. VBIBorPet31633_3187.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
OMAYGHGLER.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycBPET340100:GJBO-3204-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_BORPD
AccessionPrimary (citable) accession number: A9IU63
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways