A9IU29 (KYNB_BORPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Bpet3150

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]

Taxonomic identifier

340100 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362097

Sequences

	Sequence		Length	Mass (Da)
	A9IU29 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 9F4FA384105F76A7	FASTA	209	22,838
	10 20 30 40 50 60 MKRLWDISPP VSAASPVFPG DTPYQQHWKW SLTPDCPVNV SEIRLSPHIG AHADAPLHYS 70 80 90 100 110 120 NGAPAIGAVP LEPFLGPCRV IHALDCGPLI LPEHLRHAAD GLPPRVLVRT AEHAALDWWT 130 140 150 160 170 180 DDFSAYAPHT IEWLAERGVV LIGLDTPSID PASSKTLDSH HVILRRDMRV LENLLLDDVA 190 200 EGDYELIALP LALAQADASP VRAILRELG

References

[1]

"The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae." Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H., Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F. , Mormann S., Nakunst D., Rueckert C., Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T., Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O., Martinez-Arias R. BMC Genomics 9:449-449(2008) [PubMed: 18826580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM902716 Genomic DNA. Translation: CAP43492.1.
RefSeq	YP_001631760.1. NC_010170.1.
3D structure databases
ProteinModelPortal	A9IU29.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IU29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5816969.
GenomeReviews	Gene locus Bpet3150 in contig AM902716_GR.
KEGG	bpt:Bpet3150.
PATRIC	21167859. VBIBorPet31633_3175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686791.
OMA	FERVPAN.
ProtClustDB	CLSK920290.
Enzyme and pathway databases
BioCyc	BPET94624:BPET3150-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BORPD

Accession

Primary (citable) accession number: A9IU29

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program