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A9ITX6

- IF2_BORPD

UniProt

A9ITX6 - IF2_BORPD

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Protein
Translation initiation factor IF-2
Gene
infB, Bpet3133
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi501 – 5088GTP By similarity
Nucleotide bindingi547 – 5515GTP By similarity
Nucleotide bindingi601 – 6044GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-3172-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:Bpet3133
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 991991Translation initiation factor IF-2UniRule annotation
    PRO_1000093760Add
    BLAST

    Proteomic databases

    PRIDEiA9ITX6.

    Interactioni

    Protein-protein interaction databases

    STRINGi340100.Bpet3133.

    Structurei

    3D structure databases

    ProteinModelPortaliA9ITX6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini492 – 659168tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni501 – 5088G1 By similarity
    Regioni526 – 5305G2 By similarity
    Regioni547 – 5504G3 By similarity
    Regioni601 – 6044G4 By similarity
    Regioni637 – 6393G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiIIEVHVP.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9ITX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSNTVAQFA TELKMPANVL LEQLRSAGVD LNSVDDAVTD SDKAKLLDSL    50
    RRAHGATEGK KITLTRRQTS EIRQADATGR SRTIQVEVRK KRVFVKRDPS 100
    EIALEQARAD AAASDAAPAE PAPAAAEPSA SAPVTAPVNA PAADAPQAPA 150
    TAAPDTAAPA AETPSQPPAV EPQPAPVAQA EPEPQPEPVA KPAEAPAEPA 200
    APAAVEAHAE REAEQAPPEP AVQAEIETAP APAAESAQAA RPEPVTPKAE 250
    PAPAASKPAR AEGRRGAPVP VAAPAVDSAG REEARRAAEA EAAALREMLN 300
    RPRKVLRAPE PEAGALSGTL HKPAGKAAAP GAKKDAKPGA GGSKKTIKTA 350
    EVASTWSDDA SRKKPADTKS AAPSRDGWRA GGKGGKGGRN SRNQQAERRH 400
    EPAPQEFIAR EVHVPETISV ADLAHKMSVK AAEVIKQLMK LGQMVTINQV 450
    LDQETAMIVV EELGHVAIAA KLDDPEAFLD ETPVASEAEA LPRAPVVTVM 500
    GHVDHGKTSL LDYIRRAKVA SGEAGGITQH IGAYHVETAR GVVTFLDTPG 550
    HEAFTAMRAR GAKATDIVIL VVAADDGVMP QTREAIHHAK AGGVPLVVAV 600
    NKIDKPEANP ERVKQELVAE EVVPEEYGGD VPFVPVSAKT GAGIDDLLEN 650
    VLLQAEILEL TAPVEAPAKG LVIEARLDKG RGPVATILVQ SGTLKRGDVV 700
    LAGASFGRVR AMVDENGKQI QEAGPSIPVE IQGLTEVPAA GDELIALADE 750
    RKAREIALFR QGKFRDVKLA RQQAAKLESM FDNLGEGTQT LPLIVKTDVQ 800
    GSQEALVASL TKLSTDEVRV QVVHAAVGGI SESDINLAIA SNAVVIGFNV 850
    RAEQSAKKLA ESNGIDVRYY NIIYDAVDEV KAAMSGMLAP EKKEEVIGLV 900
    EVREVYSISR IGNVAGCMVL DGLVRRDSQI RLLRNNVVHW TGHLDSLRRF 950
    KDDVKEVKSG FDCGLTLRGS NDIQVGDQLE VFEIKEIART L 991
    Length:991
    Mass (Da):104,344
    Last modified:February 5, 2008 - v1
    Checksum:i90A833E9BB4D7211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43475.1.
    RefSeqiWP_012250037.1. NC_010170.1.
    YP_001631743.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP43475; CAP43475; Bpet3133.
    GeneIDi5816972.
    KEGGibpt:Bpet3133.
    PATRICi21167819. VBIBorPet31633_3158.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43475.1 .
    RefSeqi WP_012250037.1. NC_010170.1.
    YP_001631743.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9ITX6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet3133.

    Proteomic databases

    PRIDEi A9ITX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP43475 ; CAP43475 ; Bpet3133 .
    GeneIDi 5816972.
    KEGGi bpt:Bpet3133.
    PATRICi 21167819. VBIBorPet31633_3158.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi IIEVHVP.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci BPET340100:GJBO-3172-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiIF2_BORPD
    AccessioniPrimary (citable) accession number: A9ITX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 5, 2008
    Last modified: September 3, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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