ID   A9ITT4_BORPD            Unreviewed;       463 AA.
AC   A9ITT4;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=L-serine dehydratase {ECO:0000256|RuleBase:RU366059};
DE            EC=4.3.1.17 {ECO:0000256|RuleBase:RU366059};
GN   Name=sdaA {ECO:0000313|EMBL:CAP43462.1};
GN   OrderedLocusNames=Bpet3120 {ECO:0000313|EMBL:CAP43462.1};
OS   Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=340100 {ECO:0000313|EMBL:CAP43462.1, ECO:0000313|Proteomes:UP000001225};
RN   [1] {ECO:0000313|EMBL:CAP43462.1, ECO:0000313|Proteomes:UP000001225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-461 / DSM 12804 / CCUG 43448
RC   {ECO:0000313|Proteomes:UP000001225};
RX   PubMed=18826580; DOI=10.1186/1471-2164-9-449;
RA   Gross R., Guzman C.A., Sebaihia M., Martins Dos Santos V.A., Pieper D.H.,
RA   Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V.,
RA   Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S.,
RA   Linke B., Meyer F., Mormann S., Nakunst D., Rueckert C.,
RA   Schneiker-Bekel S., Schulze K., Vorhoelter F.J., Yevsa T., Engle J.T.,
RA   Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O.,
RA   Martinez-Arias R.;
RT   "The missing link: Bordetella petrii is endowed with both the metabolic
RT   versatility of environmental bacteria and virulence traits of pathogenic
RT   Bordetellae.";
RL   BMC Genomics 9:449-449(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00001161,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000256|ARBA:ARBA00004742}.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00008636, ECO:0000256|RuleBase:RU366059}.
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DR   EMBL; AM902716; CAP43462.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9ITT4; -.
DR   STRING; 94624.Bpet3120; -.
DR   KEGG; bpt:Bpet3120; -.
DR   eggNOG; COG1760; Bacteria.
DR   Proteomes; UP000001225; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   NCBIfam; TIGR00720; sda_mono; 1.
DR   PANTHER; PTHR30182; L-SERINE DEHYDRATASE; 1.
DR   PANTHER; PTHR30182:SF1; L-SERINE DEHYDRATASE 1; 1.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; Serine metabolism enzymes domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU366059};
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU366059};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU366059};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU366059};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366059};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU366059}.
FT   DOMAIN          4..156
FT                   /note="Serine dehydratase beta chain"
FT                   /evidence="ECO:0000259|Pfam:PF03315"
FT   DOMAIN          188..457
FT                   /note="Serine dehydratase-like alpha subunit"
FT                   /evidence="ECO:0000259|Pfam:PF03313"
SQ   SEQUENCE   463 AA;  48982 MW;  77B233E58F09A48F CRC64;
     MAVSAFDLFK IGIGPSSSHT VGPMRAALLF AQGLERDGLL PRVAGLRVEL YGSLGATGKG
     HGTDKGVLLG LMGQAPDTVD PAAIPGLLQA VRTNKSLPVL GHFAVPFVEK EHILFYRREA
     LAEHPNGMKF HAFDAAGASL RESRYLSVGG GFVVTAGAAN TQIIAAHDQL PFAFRTAREL
     VDMCRAGGYT VAQVMMQNEL TWRSQSEVET TLDRIWQVMQ DCVSRGCGIG HPEADGDLPG
     PLKVRRRAPE LYRSLTLRAE RTLSDPLSVM DWVNLYAMAV NEENAAGGRV VTAPTNGAAG
     IIPAVLHYYD RFVPGAGPQG VRDFLLTAAA IGLLYKYNAS LSGAEVGCQG EVGVACSMAA
     GALAAVLGGS VEQVENAAEI GMEHNLGLTC DPVGGLVQIP CIERNAMASV KAVNAARMAL
     RGDGHHYVSL DSVIKTMRET GADMKTKYKE TARGGLAVNI VEC
//