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A9ITA7

- GCH4_BORPD

UniProt

A9ITA7 - GCH4_BORPD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-3094-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Bpet3059
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265GTP cyclohydrolase FolE2PRO_0000372020Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340100.Bpet3059.

    Structurei

    3D structure databases

    ProteinModelPortaliA9ITA7.
    SMRiA9ITA7. Positions 22-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9ITA7-1 [UniParc]FASTAAdd to Basket

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    MNSPIDPALV MPDVQSSADT RHIPIQRVGI RGVRHPMLVA GADGAPQPTV    50
    ANWTLTVALP AEEKGTHMSR FVALLEKYRS VPMTPALFAA MARDMLPLLH 100
    AERGDITAAF PYFINKSAPV SGVQSLLDYE VQWIARAAGD QVEFELVVQV 150
    PVTSLCPCSK AISEYGAHNQ RSHVTVSVVL NGDLAMDRII RLVEDEGSCE 200
    LWGLLKRPDE KFVTERAYDN PKFVEDLVRD VAARLAAHPG VARYRVEAEN 250
    FESIHNHSAY AVVEG 265
    Length:265
    Mass (Da):29,120
    Last modified:February 5, 2008 - v1
    Checksum:i7360C30C1D27E0F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43401.1.
    RefSeqiWP_012249964.1. NC_010170.1.
    YP_001631669.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP43401; CAP43401; Bpet3059.
    GeneIDi5817475.
    KEGGibpt:Bpet3059.
    PATRICi21167661. VBIBorPet31633_3084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43401.1 .
    RefSeqi WP_012249964.1. NC_010170.1.
    YP_001631669.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9ITA7.
    SMRi A9ITA7. Positions 22-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet3059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP43401 ; CAP43401 ; Bpet3059 .
    GeneIDi 5817475.
    KEGGi bpt:Bpet3059.
    PATRICi 21167661. VBIBorPet31633_3084.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BPET340100:GJBO-3094-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiGCH4_BORPD
    AccessioniPrimary (citable) accession number: A9ITA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3