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A9ITA7

- GCH4_BORPD

UniProt

A9ITA7 - GCH4_BORPD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3094-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Bpet3059
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265GTP cyclohydrolase FolE2PRO_0000372020Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet3059.

Structurei

3D structure databases

ProteinModelPortaliA9ITA7.
SMRiA9ITA7. Positions 22-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9ITA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPIDPALV MPDVQSSADT RHIPIQRVGI RGVRHPMLVA GADGAPQPTV
60 70 80 90 100
ANWTLTVALP AEEKGTHMSR FVALLEKYRS VPMTPALFAA MARDMLPLLH
110 120 130 140 150
AERGDITAAF PYFINKSAPV SGVQSLLDYE VQWIARAAGD QVEFELVVQV
160 170 180 190 200
PVTSLCPCSK AISEYGAHNQ RSHVTVSVVL NGDLAMDRII RLVEDEGSCE
210 220 230 240 250
LWGLLKRPDE KFVTERAYDN PKFVEDLVRD VAARLAAHPG VARYRVEAEN
260
FESIHNHSAY AVVEG
Length:265
Mass (Da):29,120
Last modified:February 5, 2008 - v1
Checksum:i7360C30C1D27E0F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP43401.1.
RefSeqiWP_012249964.1. NC_010170.1.
YP_001631669.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP43401; CAP43401; Bpet3059.
GeneIDi5817475.
KEGGibpt:Bpet3059.
PATRICi21167661. VBIBorPet31633_3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP43401.1 .
RefSeqi WP_012249964.1. NC_010170.1.
YP_001631669.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9ITA7.
SMRi A9ITA7. Positions 22-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet3059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP43401 ; CAP43401 ; Bpet3059 .
GeneIDi 5817475.
KEGGi bpt:Bpet3059.
PATRICi 21167661. VBIBorPet31633_3084.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BPET340100:GJBO-3094-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiGCH4_BORPD
AccessioniPrimary (citable) accession number: A9ITA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3