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A9ITA7 (GCH4_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Bpet3059
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000372020

Sites

Site1561May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A9ITA7 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 7360C30C1D27E0F9

FASTA26529,120
        10         20         30         40         50         60 
MNSPIDPALV MPDVQSSADT RHIPIQRVGI RGVRHPMLVA GADGAPQPTV ANWTLTVALP 

        70         80         90        100        110        120 
AEEKGTHMSR FVALLEKYRS VPMTPALFAA MARDMLPLLH AERGDITAAF PYFINKSAPV 

       130        140        150        160        170        180 
SGVQSLLDYE VQWIARAAGD QVEFELVVQV PVTSLCPCSK AISEYGAHNQ RSHVTVSVVL 

       190        200        210        220        230        240 
NGDLAMDRII RLVEDEGSCE LWGLLKRPDE KFVTERAYDN PKFVEDLVRD VAARLAAHPG 

       250        260 
VARYRVEAEN FESIHNHSAY AVVEG 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP43401.1.
RefSeqYP_001631669.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9ITA7.
SMRA9ITA7. Positions 22-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet3059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP43401; CAP43401; Bpet3059.
GeneID5817475.
KEGGbpt:Bpet3059.
PATRIC21167661. VBIBorPet31633_3084.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycBPET340100:GJBO-3094-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BORPD
AccessionPrimary (citable) accession number: A9ITA7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways