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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:Bpet3018Imported
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)Imported
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001225 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet3018

Structurei

3D structure databases

ProteinModelPortaliA9ISY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 78Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini133 – 207Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini265 – 302Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
HOGENOMiHOG000281562
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 3 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

A9ISY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLVEIKVP DIGDFKEVEV IEVLVSEGDT IQAEQSLITV ESDKASMEIP
60 70 80 90 100
ASSGGVVKSV KVKVGDKVAE GKVILEVEAG EAAGADQAPA SPDKADAAAK
110 120 130 140 150
QPSSGDAPKT QGQTVEAPDV KPAADAGKGA GGIAEITVPD IGDFKEVEVI
160 170 180 190 200
EVMIAVGDTI KPEQSLITVE SDKASMEIPA SAGGVVKEVK VKVGDKVAKG
210 220 230 240 250
TAIAVVEGQG GAQAEPQKAQ APAQAQEQQP SGAASASAAA PAPAAKPAPA
260 270 280 290 300
AALEDPGLKP GQLPHASPSV RKFARELGVN LSKVKGSGPK DRITADDVRA
310 320 330 340 350
FVKQALAAPA AAAGGADGAA LGLLPWPKVD FTKFGPVEAK PLSRIKKISG
360 370 380 390 400
ANLHRNWVMI PHVTNNDEAD ITDLEALRVT LNKENEKAGI KVTMLAFLIK
410 420 430 440 450
AVVAALKKFP EFNASLDGDQ LVYKQYYHIG FAADTPNGLV VPVIRDADKK
460 470 480 490 500
GILEIAKEMG ELSKKARDGK ISPAEMQGGC FSISSLGGIG GTHFTPIINA
510 520 530 540 550
PEVAILGVSR SAHKPVWDGK QFVPRLIVPL SLSYDHRVID GAAAARFNAY
560
LGQLLADFRR IVL
Length:563
Mass (Da):58,393
Last modified:February 5, 2008 - v1
Checksum:i51178C889F4ACF4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA Translation: CAP43360.1

Genome annotation databases

EnsemblBacteriaiCAP43360; CAP43360; Bpet3018
KEGGibpt:Bpet3018

Similar proteinsi

Entry informationi

Entry nameiA9ISY2_BORPD
AccessioniPrimary (citable) accession number: A9ISY2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health