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A9ISY2

- A9ISY2_BORPD

UniProt

A9ISY2 - A9ISY2_BORPD

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-3053-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:aceFImported
    Ordered Locus Names:Bpet3018Imported
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)Imported
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi340100.Bpet3018.

    Structurei

    3D structure databases

    ProteinModelPortaliA9ISY2.
    SMRiA9ISY2. Positions 6-83, 133-212, 324-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiTEIMVAV.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9ISY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLVEIKVP DIGDFKEVEV IEVLVSEGDT IQAEQSLITV ESDKASMEIP    50
    ASSGGVVKSV KVKVGDKVAE GKVILEVEAG EAAGADQAPA SPDKADAAAK 100
    QPSSGDAPKT QGQTVEAPDV KPAADAGKGA GGIAEITVPD IGDFKEVEVI 150
    EVMIAVGDTI KPEQSLITVE SDKASMEIPA SAGGVVKEVK VKVGDKVAKG 200
    TAIAVVEGQG GAQAEPQKAQ APAQAQEQQP SGAASASAAA PAPAAKPAPA 250
    AALEDPGLKP GQLPHASPSV RKFARELGVN LSKVKGSGPK DRITADDVRA 300
    FVKQALAAPA AAAGGADGAA LGLLPWPKVD FTKFGPVEAK PLSRIKKISG 350
    ANLHRNWVMI PHVTNNDEAD ITDLEALRVT LNKENEKAGI KVTMLAFLIK 400
    AVVAALKKFP EFNASLDGDQ LVYKQYYHIG FAADTPNGLV VPVIRDADKK 450
    GILEIAKEMG ELSKKARDGK ISPAEMQGGC FSISSLGGIG GTHFTPIINA 500
    PEVAILGVSR SAHKPVWDGK QFVPRLIVPL SLSYDHRVID GAAAARFNAY 550
    LGQLLADFRR IVL 563
    Length:563
    Mass (Da):58,393
    Last modified:February 5, 2008 - v1
    Checksum:i51178C889F4ACF4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43360.1.
    RefSeqiWP_012249923.1. NC_010170.1.
    YP_001631628.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP43360; CAP43360; Bpet3018.
    GeneIDi5817454.
    KEGGibpt:Bpet3018.
    PATRICi21167575. VBIBorPet31633_3041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP43360.1 .
    RefSeqi WP_012249923.1. NC_010170.1.
    YP_001631628.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9ISY2.
    SMRi A9ISY2. Positions 6-83, 133-212, 324-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet3018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP43360 ; CAP43360 ; Bpet3018 .
    GeneIDi 5817454.
    KEGGi bpt:Bpet3018.
    PATRICi 21167575. VBIBorPet31633_3041.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi TEIMVAV.

    Enzyme and pathway databases

    BioCyci BPET340100:GJBO-3053-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448Imported.

    Entry informationi

    Entry nameiA9ISY2_BORPD
    AccessioniPrimary (citable) accession number: A9ISY2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3