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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3053-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotationImported)
Gene namesi
Name:aceFImported
Ordered Locus Names:Bpet3018Imported
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)Imported
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet3018.

Structurei

3D structure databases

ProteinModelPortaliA9ISY2.
SMRiA9ISY2. Positions 6-83, 133-212, 324-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9ISY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLVEIKVP DIGDFKEVEV IEVLVSEGDT IQAEQSLITV ESDKASMEIP
60 70 80 90 100
ASSGGVVKSV KVKVGDKVAE GKVILEVEAG EAAGADQAPA SPDKADAAAK
110 120 130 140 150
QPSSGDAPKT QGQTVEAPDV KPAADAGKGA GGIAEITVPD IGDFKEVEVI
160 170 180 190 200
EVMIAVGDTI KPEQSLITVE SDKASMEIPA SAGGVVKEVK VKVGDKVAKG
210 220 230 240 250
TAIAVVEGQG GAQAEPQKAQ APAQAQEQQP SGAASASAAA PAPAAKPAPA
260 270 280 290 300
AALEDPGLKP GQLPHASPSV RKFARELGVN LSKVKGSGPK DRITADDVRA
310 320 330 340 350
FVKQALAAPA AAAGGADGAA LGLLPWPKVD FTKFGPVEAK PLSRIKKISG
360 370 380 390 400
ANLHRNWVMI PHVTNNDEAD ITDLEALRVT LNKENEKAGI KVTMLAFLIK
410 420 430 440 450
AVVAALKKFP EFNASLDGDQ LVYKQYYHIG FAADTPNGLV VPVIRDADKK
460 470 480 490 500
GILEIAKEMG ELSKKARDGK ISPAEMQGGC FSISSLGGIG GTHFTPIINA
510 520 530 540 550
PEVAILGVSR SAHKPVWDGK QFVPRLIVPL SLSYDHRVID GAAAARFNAY
560
LGQLLADFRR IVL
Length:563
Mass (Da):58,393
Last modified:February 5, 2008 - v1
Checksum:i51178C889F4ACF4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43360.1.

Genome annotation databases

EnsemblBacteriaiCAP43360; CAP43360; Bpet3018.
KEGGibpt:Bpet3018.
PATRICi21167575. VBIBorPet31633_3041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43360.1.

3D structure databases

ProteinModelPortaliA9ISY2.
SMRiA9ISY2. Positions 6-83, 133-212, 324-563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340100.Bpet3018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP43360; CAP43360; Bpet3018.
KEGGibpt:Bpet3018.
PATRICi21167575. VBIBorPet31633_3041.

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3053-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448Imported.

Entry informationi

Entry nameiA9ISY2_BORPD
AccessioniPrimary (citable) accession number: A9ISY2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 22, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.