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A9ISQ6

- SYE1_BART1

UniProt

A9ISQ6 - SYE1_BART1

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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei241 – 2411ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:BT_0931
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Glutamate--tRNA ligase 1PRO_0000367612Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi382640.Btr_0931.

Structurei

3D structure databases

ProteinModelPortaliA9ISQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 1911"HIGH" regionAdd
BLAST
Motifi238 – 2425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
KOiK01885.
OMAiAMGWEVP.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9ISQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVITRFAPS PTGFLHIGGA RTALFNWLYA KHTGGKMLLR IEDTDRERST
60 70 80 90 100
EAAVRAIIDG LHWMGLSYDG SPISQFERAE RHRQIAEQLV ENGKAYYCYA
110 120 130 140 150
SPEELAEMRE KARAEGRPPR YDGRWRNRDH SEAPQGIKPV IRIKAPEDGE
160 170 180 190 200
TIVHDRVQGD VRFPNKDLDD FIILRSDGSP TYMHAVVVDD HDMGVTHIIR
210 220 230 240 250
GDDHLTNAAR QTIIFKAMGW DIPVMAHIPL IHGENGAKLS KRHGALGVDA
260 270 280 290 300
YRTMGYLPAA LRNYLVRLGW SHGDDELMSL QDMISWFDIE DINKGAARFD
310 320 330 340 350
LKKLDSINGH YMRMSNDQEL FDAALDILPE TDGGTEIIER LDEQRRVQFL
360 370 380 390 400
KAIPHLKERS KTLCELIDNA SFIFTQRPLQ LNEKAQMLLD KNGRTILNDL
410 420 430 440 450
YLALKACPSW DTKALDETLR SYIQTQNLKF GSIAQPLRAA LTGCTTSPGV
460 470
LDVLILLGRD ESLYRINDQL ITTVGL
Length:476
Mass (Da):53,830
Last modified:February 5, 2008 - v1
Checksum:iA806BBF8BAAA9777
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK01328.1.
RefSeqiWP_012231524.1. NC_010161.1.
YP_001609323.1. NC_010161.1.

Genome annotation databases

GeneIDi5829124.
KEGGibtr:Btr_0931.
PATRICi20549618. VBIBarTri113218_0963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK01328.1 .
RefSeqi WP_012231524.1. NC_010161.1.
YP_001609323.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9ISQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_0931.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5829124.
KEGGi btr:Btr_0931.
PATRICi 20549618. VBIBarTri113218_0963.

Phylogenomic databases

eggNOGi COG0008.
KOi K01885.
OMAi AMGWEVP.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci BTRI382640:GJEK-830-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiSYE1_BART1
AccessioniPrimary (citable) accession number: A9ISQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3