A9IQR2 (KHSE_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BT_0656

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Homoserine kinase HAMAP MF_00301		PRO_1000079015

Sequences

	Sequence		Length	Mass (Da)
	A9IQR2 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 0027CF78983CE879	FASTA	319	36,964
	10 20 30 40 50 60 MAVYTDIHPN DLKVFLTRYA IGSLLSYQGI EEGIENSNFM LETTQGRFIL TLYEKRISKD 70 80 90 100 110 120 DLPFFCRLMQ HLGQRGIPCP QPIIQNDGVM IGELAGRPAA IITFLEGEWI RQPDIDHCGE 130 140 150 160 170 180 VGTGLAQLHL AGQDFTLSRK NTLSIMDWQV LWQRCQITED ALLKEFGQKI ESELAFLQEN 190 200 210 220 230 240 WPFNLPTGII HADLFNDNVF FVNHCLSGMI DFYFACNDFF SYDLAICLNA WCFEPDYSYN 250 260 270 280 290 300 LIKARKLLEN YQKIRPLIPL ELDKIVLLAR GASLRFLLTR LYDWFNTPPD SFVIKKNPWE 310 YWHKLCFFSN VNSLSELGF

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK01090.1.
RefSeq	YP_001609085.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IQR2.
SMR	A9IQR2. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IQR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5830748.
GenomeReviews	Gene locus BT_0656 in contig AM260525_GR.
PATRIC	20549070. VBIBarTri113218_0694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_0656-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BART1

Accession

Primary (citable) accession number: A9IQR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program