A9IQQ8 (F16PA_BORPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	Bpet2744

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]

Taxonomic identifier

340100 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364471
Regions
	Region	116 – 119	4	Substrate binding By similarity
Sites
	Metal binding	91	1	Magnesium 1 By similarity
	Metal binding	113	1	Magnesium 1 By similarity
	Metal binding	113	1	Magnesium 2 By similarity
	Metal binding	115	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	116	1	Magnesium 2 By similarity
	Metal binding	283	1	Magnesium 2 By similarity
	Binding site	211	1	Substrate By similarity
	Binding site	277	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IQQ8 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 87E681FA5D600028	FASTA	342	37,631
	10 20 30 40 50 60 MKRKTLTQYL VEQQRSANAL GPEVRLLIEV VARACKAISH AVSKGALGGV LGSLESENVQ 70 80 90 100 110 120 GEVQKKLDVL SNEILLEANE WGGHLAAMAS EEMETIHLIP NRYPKGEYLL LFDPLDGSSN 130 140 150 160 170 180 IDVNVSIGTI FSVLHAPHRV AGAEEVCEQD FLQPGSQQVA AGYAVYGPQT MLVLTIGTGV 190 200 210 220 230 240 VGFTLDREMG SWVLTHENMR VPEDTKEFAI NMSNMRHWAP PVRRYIDECL AGTTGPLGKD 250 260 270 280 290 300 YNMRWIASMV ADVHRIMTRG GIFMYPWDAR EPGKAGKLRL MYEANPMSMI IEQAGGAAID 310 320 330 340 GTRRILDIQP DKLHQRVSVI LGSKNEVERV GRYHAEAAQA PA

References

[1]

"The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae." Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H., Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F. , Mormann S., Nakunst D., Rueckert C., Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T., Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O., Martinez-Arias R. BMC Genomics 9:449-449(2008) [PubMed: 18826580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM902716 Genomic DNA. Translation: CAP43086.1.
RefSeq	YP_001631354.1. NC_010170.1.
3D structure databases
ProteinModelPortal	A9IQQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IQQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5820397.
GenomeReviews	Gene locus Bpet2744 in contig AM902716_GR.
KEGG	bpt:Bpet2744.
PATRIC	21166994. VBIBorPet31633_2754.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG731261.
OMA	HWEAPVQ.
ProtClustDB	PRK09293.
Enzyme and pathway databases
BioCyc	BPET94624:BPET2744-MONOMER.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_BORPD

Accession

Primary (citable) accession number: A9IQQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program