Reviewed, UniProtKB/Swiss-Prot A9IQP2 (DXS_BART1)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BT_0649

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000079082

Sequences

	Sequence		Length	Mass (Da)
	A9IQP2-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: FC0ACAC1AF438A66	FASTA	635	69,381
	10 20 30 40 50 60 MSQVLTPLLD RVCFPQDLRA LPESYLVQLA NELRTETIDA VSVTGGHLGA GLGVVELTVA 70 80 90 100 110 120 LHYIFNTPED RIIWDVGHQT YPHKILTGRR EKIRTLRQEG GLSGFTKRVE SVYDPFGAGH 130 140 150 160 170 180 SSTSISAGLG MAVASALKEE KKRKVIAVIG DGAMSAGMAY EAMNNAGALN ARLIVILNDN 190 200 210 220 230 240 DMSIAPPTGS MSAHLARLVS RPSYRHLRER VKMLSEKLPK FFWDKARRSE EFARGLLVGG 250 260 270 280 290 300 TLFDELGFYY VGPIDGHNLG HLLPVLKNVR EYPHGPVLVH VVTHKGKGYP PAEASSDKYH 310 320 330 340 350 360 GVNRFDVTTG KQVKASSNIL PYTKVFSKAL VEEACHDDKI VGITAAMPTG TGLDSFAEKF 370 380 390 400 410 420 PEKMFDVGIA EQHAVTFAAG LACEGYKPFV AIYSTFLQRA YDQIIHDVSI QKLPVRFAID 430 440 450 460 470 480 RAGFVGADGA THAGSFDIVF LATLPEFVVM APSDELELMH MVRTAAAYDQ GPISFRYPRG 490 500 510 520 530 540 EGIGIDLPQR GEILEIGKGR VLREGNRIAL VCFGTRMSEV LRAADRLGAK GLSTTVADAR 550 560 570 580 590 600 FAKPLDKDLM RRLAREHEVL VTIEEGAIGG FGAHLLQFLA QEGLLEHGLK VRTLKFPDEY 610 620 630 LNHGSPEKVL STIGLDAMGI VNTVLTVVGR EIRME

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260525 Genomic DNA. Translation: CAK01083.1.
RefSeq	YP_001609078.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5829877.
GenomeReviews	Gene locus BT_0649 in contig AM260525_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BART1

Accession

Primary (citable) accession number: A9IQP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)