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A9IQK8

- ISPE_BART1

UniProt

A9IQK8 - ISPE_BART1

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Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ispE

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotation

Catalytic activityi

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei17 – 171UniRule annotation
Active sitei145 – 1451UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 11311ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-567-MONOMER.
UniPathwayiUPA00056; UER00094.

Names & Taxonomyi

Protein namesi
Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
Short name:
CMKUniRule annotation
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
Gene namesi
Name:ispEUniRule annotation
Ordered Locus Names:BT_0633
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2992994-diphosphocytidyl-2-C-methyl-D-erythritol kinasePRO_0000335702Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_0633.

Structurei

3D structure databases

ProteinModelPortaliA9IQK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1947.
HOGENOMiHOG000291826.
KOiK00919.
OMAiCVYSETA.
OrthoDBiEOG62VNQ2.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.

Sequencei

Sequence statusi: Complete.

A9IQK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKFRSKDMS HVFTPIKLNL ALHVVGQRAD GYHLIESLVY FSLSGDYLHY
60 70 80 90 100
EPCESDQFVL TGPFAKELIS HPDNLVVRAR DFMHKTFPEG AHPTFFRLVK
110 120 130 140 150
TLPVASGIGG GSGDAAGVIS ILRQQWNLDC PFEKLAKMSL VLGADVPMCL
160 170 180 190 200
FALEYHQPLL VKGIGQEIIQ LKEACSLAIV LVNHGQEIST QAVFKALDKR
210 220 230 240 250
HHPSLKIDPI ALKSVDSLVE ALQETRNDLF SPALKMAPQL TQVLSILDEC
260 270 280 290
GSLFSRMSGT GATCFGIFKN QQTAQQAALL IKSMHPNWFV KSIMTLGTI
Length:299
Mass (Da):33,037
Last modified:February 5, 2008 - v1
Checksum:i36F852071A1DDE53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK01070.1.
RefSeqiWP_012231176.1. NC_010161.1.
YP_001609065.1. NC_010161.1.

Genome annotation databases

GeneIDi5830332.
KEGGibtr:Btr_0633.
PATRICi20549020. VBIBarTri113218_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK01070.1 .
RefSeqi WP_012231176.1. NC_010161.1.
YP_001609065.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9IQK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_0633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5830332.
KEGGi btr:Btr_0633.
PATRICi 20549020. VBIBarTri113218_0669.

Phylogenomic databases

eggNOGi COG1947.
HOGENOMi HOG000291826.
KOi K00919.
OMAi CVYSETA.
OrthoDBi EOG62VNQ2.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00094 .
BioCyci BTRI382640:GJEK-567-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00061. IspE.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF010376. IspE. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00154. ispE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiISPE_BART1
AccessioniPrimary (citable) accession number: A9IQK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3