Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A9INR9 (LPXB_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Bpet2522
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000191462

Sequences

Sequence LengthMass (Da)Tools
A9INR9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: CFB713FB61288E74

FASTA39343,020
        10         20         30         40         50         60 
MSLSIGMVAG EPSGDLLASR VIAGLRRDET VQCQGIGGPA MQAAGFDAWH PMHALTVFGY 

        70         80         90        100        110        120 
VDALKRLPSL LRTYGDVKRR WLASPPSVFV GVDAPDFNLK LELALRQAGT PTVHFVGPSI 

       130        140        150        160        170        180 
WAWRYERIHK IREAVSHMLV LFPFEEELYR KEGIPVTYVG HPLADAIPMQ PDRAAARQRL 

       190        200        210        220        230        240 
GLDADARVLA ILPGSRSSEI RILAPRFLQA AQQLQRRDPG LVCVVPMVNA QRRAEFEAIL 

       250        260        270        280        290        300 
AQYPVPGLRC LTAEDAASGG LPVAWSALEA SNAVLVASGT ATLEAALFKR PMVISYYLSP 

       310        320        330        340        350        360 
WMRRIMAWKS GQQRPYLPWV GLPNVLLRDF AVPELLQDDA TPDKLAEATW AALTDDAQAA 

       370        380        390 
RVEARFAAMH RDLTRDTATL AARAILEVAH GAA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP42864.1.
RefSeqYP_001631132.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9INR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet2522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP42864; CAP42864; Bpet2522.
GeneID5820480.
KEGGbpt:Bpet2522.
PATRIC21166522. VBIBorPet31633_2523.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycBPET340100:GJBO-2549-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_BORPD
AccessionPrimary (citable) accession number: A9INR9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways