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A9INR9

- LPXB_BORPD

UniProt

A9INR9 - LPXB_BORPD

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-2549-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Bpet2522
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Lipid-A-disaccharide synthasePRO_1000191462Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340100.Bpet2522.

    Structurei

    3D structure databases

    ProteinModelPortaliA9INR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9INR9-1 [UniParc]FASTAAdd to Basket

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    MSLSIGMVAG EPSGDLLASR VIAGLRRDET VQCQGIGGPA MQAAGFDAWH    50
    PMHALTVFGY VDALKRLPSL LRTYGDVKRR WLASPPSVFV GVDAPDFNLK 100
    LELALRQAGT PTVHFVGPSI WAWRYERIHK IREAVSHMLV LFPFEEELYR 150
    KEGIPVTYVG HPLADAIPMQ PDRAAARQRL GLDADARVLA ILPGSRSSEI 200
    RILAPRFLQA AQQLQRRDPG LVCVVPMVNA QRRAEFEAIL AQYPVPGLRC 250
    LTAEDAASGG LPVAWSALEA SNAVLVASGT ATLEAALFKR PMVISYYLSP 300
    WMRRIMAWKS GQQRPYLPWV GLPNVLLRDF AVPELLQDDA TPDKLAEATW 350
    AALTDDAQAA RVEARFAAMH RDLTRDTATL AARAILEVAH GAA 393
    Length:393
    Mass (Da):43,020
    Last modified:February 5, 2008 - v1
    Checksum:iCFB713FB61288E74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42864.1.
    RefSeqiWP_012249431.1. NC_010170.1.
    YP_001631132.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP42864; CAP42864; Bpet2522.
    GeneIDi5820480.
    KEGGibpt:Bpet2522.
    PATRICi21166522. VBIBorPet31633_2523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42864.1 .
    RefSeqi WP_012249431.1. NC_010170.1.
    YP_001631132.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9INR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet2522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP42864 ; CAP42864 ; Bpet2522 .
    GeneIDi 5820480.
    KEGGi bpt:Bpet2522.
    PATRICi 21166522. VBIBorPet31633_2523.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BPET340100:GJBO-2549-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiLPXB_BORPD
    AccessioniPrimary (citable) accession number: A9INR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3