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A9INR9

- LPXB_BORPD

UniProt

A9INR9 - LPXB_BORPD

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Bpet2522
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBPET340100:GJBO-2549-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Bpet2522
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191462Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet2522.

Structurei

3D structure databases

ProteinModelPortaliA9INR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A9INR9-1 [UniParc]FASTAAdd to Basket

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MSLSIGMVAG EPSGDLLASR VIAGLRRDET VQCQGIGGPA MQAAGFDAWH    50
PMHALTVFGY VDALKRLPSL LRTYGDVKRR WLASPPSVFV GVDAPDFNLK 100
LELALRQAGT PTVHFVGPSI WAWRYERIHK IREAVSHMLV LFPFEEELYR 150
KEGIPVTYVG HPLADAIPMQ PDRAAARQRL GLDADARVLA ILPGSRSSEI 200
RILAPRFLQA AQQLQRRDPG LVCVVPMVNA QRRAEFEAIL AQYPVPGLRC 250
LTAEDAASGG LPVAWSALEA SNAVLVASGT ATLEAALFKR PMVISYYLSP 300
WMRRIMAWKS GQQRPYLPWV GLPNVLLRDF AVPELLQDDA TPDKLAEATW 350
AALTDDAQAA RVEARFAAMH RDLTRDTATL AARAILEVAH GAA 393
Length:393
Mass (Da):43,020
Last modified:February 5, 2008 - v1
Checksum:iCFB713FB61288E74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP42864.1.
RefSeqiWP_012249431.1. NC_010170.1.
YP_001631132.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP42864; CAP42864; Bpet2522.
GeneIDi5820480.
KEGGibpt:Bpet2522.
PATRICi21166522. VBIBorPet31633_2523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP42864.1 .
RefSeqi WP_012249431.1. NC_010170.1.
YP_001631132.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9INR9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 340100.Bpet2522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP42864 ; CAP42864 ; Bpet2522 .
GeneIDi 5820480.
KEGGi bpt:Bpet2522.
PATRICi 21166522. VBIBorPet31633_2523.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BPET340100:GJBO-2549-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiLPXB_BORPD
AccessioniPrimary (citable) accession number: A9INR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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