Reviewed, UniProtKB/Swiss-Prot A9IMB2 (PROA_BART1)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	BT_0174

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_0000340872

Sequences

	Sequence		Length	Mass (Da)
	A9IMB2-1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: 799420BB60213866	FASTA	409	44,016
	10 20 30 40 50 60 MGQKARSAAA ALAVASSEQK NNALEMIALS LEAHSDEILR ANCLDLEKAT QNNLKAAMVD 70 80 90 100 110 120 RLKLDELRLA AMIDSVRQVA RLSDPVGQIM SAWTRPNGLH ISRVRTPLGV IGIIYESRPN 130 140 150 160 170 180 VTIDASSLCL KAGNAVILRG GSDSFHSSYA LHCALVQGLE HSGLPKSAIQ MVGTTDRAAV 190 200 210 220 230 240 GEILKGLDGA IDVIVPRGGK SLVARVQSDA RVPVFAHLEG LCHIYIDKSA DLDMARNIVL 250 260 270 280 290 300 NAKLRRTGIC GAVETVLIDN EALKKFLPVL TALQEKGCEI RATEDIAFLV PDVKLASEED 310 320 330 340 350 360 WSHEYLDAIL SVKTVEGVEG AISHIKRYSS GHTESIIAED MEVVKKFFNH LDSAILLHNA 370 380 390 400 STQFADGGEF GFGMEIGIAT GKMHARGPIG VEQLTSFQYH IKGNGQVRA

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260525 Genomic DNA. Translation: CAK00658.1. Different initiation.
RefSeq	YP_001608653.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5829224.
GenomeReviews	Gene locus BT_0174 in contig AM260525_GR.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_BART1

Accession

Primary (citable) accession number: A9IMB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	June 16, 2009
This is version 13 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)