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A9IM41 (FTHS_BART1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:BT_0147
OrganismBartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]
Taxonomic identifier382640 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000333312

Regions

Nucleotide binding66 – 738ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9IM41 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: D3970AB1B11E2183

FASTA55760,207
        10         20         30         40         50         60 
MHKTDIEIAH TAKKQHITEI AQKIGIAHEN LIPYGHDKAK ISSSYIKSLN NNPDGKLILV 

        70         80         90        100        110        120 
TAINPTPAGE GKTTTTVGLS DALNLIGKKT IATLREPSLG PCFGVKGGAA GGGYAQVIPM 

       130        140        150        160        170        180 
DDLNLHFTGD FHAITAAHNL LAAMIDNHIY WGNPLNIDPR RIVWKRVLDM NDRALRDIVI 

       190        200        210        220        230        240 
SLGGITNGFP RQTGFDITVA SEIMALLCLS ENLENLTQRL KKIIVAYRHD KTPVTVADLN 

       250        260        270        280        290        300 
AEGAMAVLLK DAIQPNLVQT IENNPVLVHG GPFANIAHGC NSVIATKTAL KLADYVVTEA 

       310        320        330        340        350        360 
GFGADLGAEK FFNIKCRQTG IVPNATVIVA TIRALKMNGG VDKNNLTEEN ITALEKGAAN 

       370        380        390        400        410        420 
LVRHIKNMAL YGIPCVVAIN HFDSDSDAEI RTLQKIVATT GHKALICKHW EQGGKGAVAL 

       430        440        450        460        470        480 
AQELVTLIEK QDSDFKVLYQ DDIPLVQKIN CIITKLYGGR GAIISATILK QLESWEKEGF 

       490        500        510        520        530        540 
GTYPICMAKT PYSFSADPKQ YGAPVDFEIP VREVRLCAGA GFIVVICGDV MTMPGLPHYP 

       550 
AAEKIHLDEN DQIQGLS 

« Hide

References

[1]"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeqYP_001608629.1. NC_010161.1.

3D structure databases

ProteinModelPortalA9IM41.
SMRA9IM41. Positions 5-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382640.Btr_0147.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5830260.
KEGGbtr:Btr_0147.
PATRIC20548012. VBIBarTri113218_0170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000291281.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2506708.

Enzyme and pathway databases

BioCycBTRI382640:GJEK-129-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BART1
AccessionPrimary (citable) accession number: A9IM41
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways