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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-129-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BT_0147
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000333312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_0147.

Structurei

3D structure databases

ProteinModelPortaliA9IM41.
SMRiA9IM41. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000291281.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9IM41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKTDIEIAH TAKKQHITEI AQKIGIAHEN LIPYGHDKAK ISSSYIKSLN
60 70 80 90 100
NNPDGKLILV TAINPTPAGE GKTTTTVGLS DALNLIGKKT IATLREPSLG
110 120 130 140 150
PCFGVKGGAA GGGYAQVIPM DDLNLHFTGD FHAITAAHNL LAAMIDNHIY
160 170 180 190 200
WGNPLNIDPR RIVWKRVLDM NDRALRDIVI SLGGITNGFP RQTGFDITVA
210 220 230 240 250
SEIMALLCLS ENLENLTQRL KKIIVAYRHD KTPVTVADLN AEGAMAVLLK
260 270 280 290 300
DAIQPNLVQT IENNPVLVHG GPFANIAHGC NSVIATKTAL KLADYVVTEA
310 320 330 340 350
GFGADLGAEK FFNIKCRQTG IVPNATVIVA TIRALKMNGG VDKNNLTEEN
360 370 380 390 400
ITALEKGAAN LVRHIKNMAL YGIPCVVAIN HFDSDSDAEI RTLQKIVATT
410 420 430 440 450
GHKALICKHW EQGGKGAVAL AQELVTLIEK QDSDFKVLYQ DDIPLVQKIN
460 470 480 490 500
CIITKLYGGR GAIISATILK QLESWEKEGF GTYPICMAKT PYSFSADPKQ
510 520 530 540 550
YGAPVDFEIP VREVRLCAGA GFIVVICGDV MTMPGLPHYP AAEKIHLDEN

DQIQGLS
Length:557
Mass (Da):60,207
Last modified:February 5, 2008 - v1
Checksum:iD3970AB1B11E2183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeqiWP_012230481.1. NC_010161.1.
YP_001608629.1. NC_010161.1.

Genome annotation databases

GeneIDi5830260.
KEGGibtr:Btr_0147.
PATRICi20548012. VBIBarTri113218_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeqiWP_012230481.1. NC_010161.1.
YP_001608629.1. NC_010161.1.

3D structure databases

ProteinModelPortaliA9IM41.
SMRiA9IM41. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382640.Btr_0147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5830260.
KEGGibtr:Btr_0147.
PATRICi20548012. VBIBarTri113218_0170.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000291281.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciBTRI382640:GJEK-129-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiFTHS_BART1
AccessioniPrimary (citable) accession number: A9IM41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.