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A9IM41

- FTHS_BART1

UniProt

A9IM41 - FTHS_BART1

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, BT_0147
Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-129-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BT_0147
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000333312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_0147.

Structurei

3D structure databases

ProteinModelPortaliA9IM41.
SMRiA9IM41. Positions 5-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000291281.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9IM41-1 [UniParc]FASTAAdd to Basket

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MHKTDIEIAH TAKKQHITEI AQKIGIAHEN LIPYGHDKAK ISSSYIKSLN    50
NNPDGKLILV TAINPTPAGE GKTTTTVGLS DALNLIGKKT IATLREPSLG 100
PCFGVKGGAA GGGYAQVIPM DDLNLHFTGD FHAITAAHNL LAAMIDNHIY 150
WGNPLNIDPR RIVWKRVLDM NDRALRDIVI SLGGITNGFP RQTGFDITVA 200
SEIMALLCLS ENLENLTQRL KKIIVAYRHD KTPVTVADLN AEGAMAVLLK 250
DAIQPNLVQT IENNPVLVHG GPFANIAHGC NSVIATKTAL KLADYVVTEA 300
GFGADLGAEK FFNIKCRQTG IVPNATVIVA TIRALKMNGG VDKNNLTEEN 350
ITALEKGAAN LVRHIKNMAL YGIPCVVAIN HFDSDSDAEI RTLQKIVATT 400
GHKALICKHW EQGGKGAVAL AQELVTLIEK QDSDFKVLYQ DDIPLVQKIN 450
CIITKLYGGR GAIISATILK QLESWEKEGF GTYPICMAKT PYSFSADPKQ 500
YGAPVDFEIP VREVRLCAGA GFIVVICGDV MTMPGLPHYP AAEKIHLDEN 550
DQIQGLS 557
Length:557
Mass (Da):60,207
Last modified:February 5, 2008 - v1
Checksum:iD3970AB1B11E2183
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeqiWP_012230481.1. NC_010161.1.
YP_001608629.1. NC_010161.1.

Genome annotation databases

GeneIDi5830260.
KEGGibtr:Btr_0147.
PATRICi20548012. VBIBarTri113218_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1 .
RefSeqi WP_012230481.1. NC_010161.1.
YP_001608629.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9IM41.
SMRi A9IM41. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_0147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5830260.
KEGGi btr:Btr_0147.
PATRICi 20548012. VBIBarTri113218_0170.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000291281.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BTRI382640:GJEK-129-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiFTHS_BART1
AccessioniPrimary (citable) accession number: A9IM41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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