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A9IM41

- FTHS_BART1

UniProt

A9IM41 - FTHS_BART1

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-129-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BT_0147
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000333312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_0147.

Structurei

3D structure databases

ProteinModelPortaliA9IM41.
SMRiA9IM41. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000291281.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9IM41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKTDIEIAH TAKKQHITEI AQKIGIAHEN LIPYGHDKAK ISSSYIKSLN
60 70 80 90 100
NNPDGKLILV TAINPTPAGE GKTTTTVGLS DALNLIGKKT IATLREPSLG
110 120 130 140 150
PCFGVKGGAA GGGYAQVIPM DDLNLHFTGD FHAITAAHNL LAAMIDNHIY
160 170 180 190 200
WGNPLNIDPR RIVWKRVLDM NDRALRDIVI SLGGITNGFP RQTGFDITVA
210 220 230 240 250
SEIMALLCLS ENLENLTQRL KKIIVAYRHD KTPVTVADLN AEGAMAVLLK
260 270 280 290 300
DAIQPNLVQT IENNPVLVHG GPFANIAHGC NSVIATKTAL KLADYVVTEA
310 320 330 340 350
GFGADLGAEK FFNIKCRQTG IVPNATVIVA TIRALKMNGG VDKNNLTEEN
360 370 380 390 400
ITALEKGAAN LVRHIKNMAL YGIPCVVAIN HFDSDSDAEI RTLQKIVATT
410 420 430 440 450
GHKALICKHW EQGGKGAVAL AQELVTLIEK QDSDFKVLYQ DDIPLVQKIN
460 470 480 490 500
CIITKLYGGR GAIISATILK QLESWEKEGF GTYPICMAKT PYSFSADPKQ
510 520 530 540 550
YGAPVDFEIP VREVRLCAGA GFIVVICGDV MTMPGLPHYP AAEKIHLDEN

DQIQGLS
Length:557
Mass (Da):60,207
Last modified:February 5, 2008 - v1
Checksum:iD3970AB1B11E2183
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeqiYP_001608629.1. NC_010161.1.

Genome annotation databases

GeneIDi5830260.
KEGGibtr:Btr_0147.
PATRICi20548012. VBIBarTri113218_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00634.1 .
RefSeqi YP_001608629.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9IM41.
SMRi A9IM41. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_0147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5830260.
KEGGi btr:Btr_0147.
PATRICi 20548012. VBIBarTri113218_0170.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000291281.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BTRI382640:GJEK-129-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiFTHS_BART1
AccessioniPrimary (citable) accession number: A9IM41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3