Reviewed, UniProtKB/Swiss-Prot A9IM41 (FTHS_BART1)

Names and origin

Protein names

Recommended name:
    Formate--tetrahydrofolate ligase
    EC=6.3.4.3
Alternative name(s):
    Formyltetrahydrofolate synthetase
      Short name=FHS
      Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	BT_0147

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000333312
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IM41-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: D3970AB1B11E2183	FASTA	557	60,207
	10 20 30 40 50 60 MHKTDIEIAH TAKKQHITEI AQKIGIAHEN LIPYGHDKAK ISSSYIKSLN NNPDGKLILV 70 80 90 100 110 120 TAINPTPAGE GKTTTTVGLS DALNLIGKKT IATLREPSLG PCFGVKGGAA GGGYAQVIPM 130 140 150 160 170 180 DDLNLHFTGD FHAITAAHNL LAAMIDNHIY WGNPLNIDPR RIVWKRVLDM NDRALRDIVI 190 200 210 220 230 240 SLGGITNGFP RQTGFDITVA SEIMALLCLS ENLENLTQRL KKIIVAYRHD KTPVTVADLN 250 260 270 280 290 300 AEGAMAVLLK DAIQPNLVQT IENNPVLVHG GPFANIAHGC NSVIATKTAL KLADYVVTEA 310 320 330 340 350 360 GFGADLGAEK FFNIKCRQTG IVPNATVIVA TIRALKMNGG VDKNNLTEEN ITALEKGAAN 370 380 390 400 410 420 LVRHIKNMAL YGIPCVVAIN HFDSDSDAEI RTLQKIVATT GHKALICKHW EQGGKGAVAL 430 440 450 460 470 480 AQELVTLIEK QDSDFKVLYQ DDIPLVQKIN CIITKLYGGR GAIISATILK QLESWEKEGF 490 500 510 520 530 540 GTYPICMAKT PYSFSADPKQ YGAPVDFEIP VREVRLCAGA GFIVVICGDV MTMPGLPHYP 550 AAEKIHLDEN DQIQGLS

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260525 Genomic DNA. Translation: CAK00634.1.
RefSeq	YP_001608629.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5830260.
GenomeReviews	Gene locus BT_0147 in contig AM260525_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GMKGGAT.
Family and domain databases
HAMAP	MF_01543. [Tree]
InterPro	IPR000559. For_THF_ligase. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_BART1

Accession

Primary (citable) accession number: A9IM41

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)