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A9ILN1

- PNCB_BART1

UniProt

A9ILN1 - PNCB_BART1

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, BT_0089
Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBTRI382640:GJEK-79-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:BT_0089
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000146831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382640.Btr_0089.

Structurei

3D structure databases

ProteinModelPortaliA9ILN1.
SMRiA9ILN1. Positions 1-425.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000274489.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9ILN1-1 [UniParc]FASTAAdd to Basket

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MNHPDIARRV YNHTWKLDPI IRSLLDTDFY KLLMVQMIWG LYPTVNVTFS    50
LINRTKTIRL ADDIDESELR AQLDHALSLR FTKKEMIWLA GNTFYGRKQI 100
FEPDFLQWLE NFQLPEYELA RKDGQYILHF HGSWAHSSMW EIPALAIISE 150
LRSRAALKKL DRFALDVLYA RAKAKMWRKV ERLKKLPDIK ISDFGTRRRH 200
SFLWQRWCVE ALKEGIGDSF TGTSNVLLAM DTDLEALGTN AHELPMVIAA 250
LSNNDDELRR APYQVLQDWN RYYGGNLLIV LPDTFGTEAF LCDAPDWVAD 300
WTGFRPDSAP PIEGGERIIQ WWKEKGQDPR EKLLIFSDAL DVDTIEKTYH 350
HFHGKVRMSF GWGTDLTNDF TGCAPQEIAT LDALSLVCKV THANGRPAVK 400
LSDNPEKTIG DSKEVQRYLN FFGNKKRVAR PVKM 434
Length:434
Mass (Da):50,207
Last modified:February 5, 2008 - v1
Checksum:iF00387A91F670DBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00583.1.
RefSeqiYP_001608578.1. NC_010161.1.

Genome annotation databases

GeneIDi5830201.
KEGGibtr:Btr_0089.
PATRICi20547894. VBIBarTri113218_0111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260525 Genomic DNA. Translation: CAK00583.1 .
RefSeqi YP_001608578.1. NC_010161.1.

3D structure databases

ProteinModelPortali A9ILN1.
SMRi A9ILN1. Positions 1-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382640.Btr_0089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5830201.
KEGGi btr:Btr_0089.
PATRICi 20547894. VBIBarTri113218_0111.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000274489.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BTRI382640:GJEK-79-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors."
    Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.
    Nat. Genet. 39:1469-1476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIP 105476 / IBS 506.

Entry informationi

Entry nameiPNCB_BART1
AccessioniPrimary (citable) accession number: A9ILN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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