A9ILL7 (AROA_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BT_0084

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000077980

Sequences

	Sequence		Length	Mass (Da)
	A9ILL7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 37F03D33DF17F8B0	FASTA	442	47,513
	10 20 30 40 50 60 MQKAIPITAY KSSSLSGKIR IPGDKSISHR SLILGGLANG ETYIHGLLES ADVLNTASAM 70 80 90 100 110 120 QAMGACIIKK DDFWIIRGTG NGCLLAAQKP LDFGNAGTGA RLVMGMVGPY HMKTTFIGDA 130 140 150 160 170 180 SLSKRPMGRI LDPLRLMGVE IEATHGDHLP LTLYGPKMAN PIRYHVPIAS SQVKSAILLA 190 200 210 220 230 240 GLNTAGITTV IEPVLTRDHT EKMLKAFGAT LEIERDKEGA RLIHLYGHPH LTGQTIHIPG 250 260 270 280 290 300 DPSSAAFLII AALLVEDSDI TIENVLINNS RIGLIETLWE MGAHIEFLNQ RQTGGEDVAD 310 320 330 340 350 360 LRIKSSVLKG VTVPKERAPS MIDEYPALAV AAAFAEGKTV MLGIEELRVK ESDRLSAVAQ 370 380 390 400 410 420 GLKINCVDCE EGQDFLVVYG KGSAKGLGGG YVSTHLDHRI AMCFLTFGLV SEKPVTIDDQ 430 440 RMIATSFPEF IPFIKQLGGK IA

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK00579.1.
RefSeq	YP_001608574.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9ILL7.
SMR	A9ILL7. Positions 6-441.
ModBase	Search...
Protein-protein interaction databases
STRING	A9ILL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5829947.
GenomeReviews	Gene locus BT_0084 in contig AM260525_GR.
PATRIC	20547886. VBIBarTri113218_0107.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	LECANIS.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_0084-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BART1

Accession

Primary (citable) accession number: A9ILL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program