Reviewed, UniProtKB/Swiss-Prot A9ILI4 (ARGB_BART1)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	BT_0069

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Acetylglutamate kinase HAMAP MF_00082		PRO_1000075302
Regions
	Region	72 – 73	2	Substrate binding By similarity
Sites
	Binding site	94	1	Substrate By similarity
	Binding site	199	1	Substrate By similarity
	Site	37	1	Transition state stabilizer By similarity
	Site	259	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9ILI4-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: EB347A0E717E7FD1	FASTA	301	32,147
	10 20 30 40 50 60 MDDAKNSAVD VLEKQAAFLS SALPYMQKYE NETVVVKYGG HAMGDPALGR AFARDIALLK 70 80 90 100 110 120 QSGINPVVVH GGGPQIAEIL MKMGIESRFE NGLRVTDERI VEVVEMVLAG SINKEIVALI 130 140 150 160 170 180 NAEGEWAIGL CGKDGNMVFA EKAYRTVIDP DSHIERVLDL GFVGEPIEVD RTLLDLLACS 190 200 210 220 230 240 EMIPVLAPVA PGRDGKTYNI NADIFAGAIA GALEAKRLLF LTDVPGVLDK QGKLLKELTV 250 260 270 280 290 300 SEAEKLIKNG TISGGMIPKV ETCVKALQNG VEGVVILNGK TPHSVLLELF TEQGVGTLIV S

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260525 Genomic DNA. Translation: CAK00568.1.
RefSeq	YP_001608563.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5829012.
GenomeReviews	Gene locus BT_0069 in contig AM260525_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BART1

Accession

Primary (citable) accession number: A9ILI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)