Reviewed, UniProtKB/Swiss-Prot A9IL83 (SAHH_BART1)

Names and origin

Protein names

Recommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	BT_0032

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Adenosylhomocysteinase HAMAP MF_00563		PRO_1000082275
Regions
	Region	218 – 383	166	NAD binding By similarity
Sites
	Binding site	56	1	Substrate By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9IL83-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 7D985E4FC23A785D	FASTA	465	50,972
	10 20 30 40 50 60 MTAQDFVVKD IGLAAYGRKE LDIAETEMPG LMACRKEFSS SQPLRGARIS GSLHMTIQTA 70 80 90 100 110 120 VLIETLKAIG ADIRWSSSNI FSTQDHAAAA IAATGIPVFA VKGETLEEYW TYIDAIFQWP 130 140 150 160 170 180 DGHPSNMILD DGADATNYIL VGSRAEQNKD ILSHPKTEEE EIFFKQIQKR MDATPGFFTR 190 200 210 220 230 240 QRAAIKGVSE ETTTGVNRLY QLQKEGLLPF PAINVNDSVT KSKFDNKYGC KESLVDGIRR 250 260 270 280 290 300 GTDVMIAGKT AIVCGYGDVG KGSAASLSGA GARVKVTEID PICALQAAMD GYEVVNLDDA 310 320 330 340 350 360 ASSADIIITT TGNKDVVRLD HMRQVKDMCI LGNIGHFDNE IQVAALRNLP WTNIKPQVDM 370 380 390 400 410 420 ITFPDGKRII LLSEGRLLNL GNATGHPSFV MSASFTNQVL AQIELFTRAE HYTNEVTVLP 430 440 450 460 KNLDEKVARL HLDRLGIKLT VLSEEQAAYI GVTPQGPYKP NHYRY

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM260525 Genomic DNA. Translation: CAK00536.1.
RefSeq	YP_001608531.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5830095.
GenomeReviews	Gene locus BT_0032 in contig AM260525_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HMRAMKD.
Family and domain databases
HAMAP	MF_00563. [Tree]
InterPro	IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR000043. S-Ado-L-homoCys_hydrolase. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMs	TIGR00936. ahcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_BART1

Accession

Primary (citable) accession number: A9IL83

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)