ID   AROE_BART1              Reviewed;         290 AA.
AC   A9IKY5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BT_0003;
OS   Bartonella tribocorum (strain CIP 105476 / IBS 506).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=382640;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18037886; DOI=10.1038/ng.2007.38;
RA   Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G.,
RA   Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
RT   "Genomic analysis of Bartonella identifies type IV secretion systems
RT   as host adaptability factors.";
RL   Nat. Genet. 39:1469-1476(2007).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AM260525; CAK00508.1; -; Genomic_DNA.
DR   RefSeq; YP_001608503.1; -.
DR   GeneID; 5829772; -.
DR   GenomeReviews; AM260525_GR; BT_0003.
DR   OMA; A9IKY5; CEVVIAN.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    290       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000078113.
FT   NP_BIND     135    139       NADP (By similarity).
FT   ACT_SITE     75     75       Proton acceptor (Potential).
SQ   SEQUENCE   290 AA;  32724 MW;  525CA006A61B8609 CRC64;
     MVDLTIEKTK YPRAFVVGSP IHHSKSPRIH NFWLKQYGLQ GEYLAQEVTS EKFNHFITSF
     KKIGFCGGNV TLPHKQEAFR LADYKDKTAT IIGAANTLWY EGDKLCATNS DTYGFSANLD
     DFASDWGGET ALVFGAGGAA RAILYALKER GFEQIYLVNR TKQRADNLAQ HFGKNIKVYD
     WHKIHEILYQ ADLIVNTTSI GIKNPEEKSD SFFCDFHKAK KTALVTDIVY TPLITPFLQQ
     AKSCGLKTVD GLGMLLHQAV IGFERWFGVR PQVTKALRTA ILEDMSEERE
//