A9IKY5 (AROE_BART1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BT_0003

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506) [Complete proteome] [HAMAP]

Taxonomic identifier

382640 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000078113
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	75	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A9IKY5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 525CA006A61B8609	FASTA	290	32,724
	10 20 30 40 50 60 MVDLTIEKTK YPRAFVVGSP IHHSKSPRIH NFWLKQYGLQ GEYLAQEVTS EKFNHFITSF 70 80 90 100 110 120 KKIGFCGGNV TLPHKQEAFR LADYKDKTAT IIGAANTLWY EGDKLCATNS DTYGFSANLD 130 140 150 160 170 180 DFASDWGGET ALVFGAGGAA RAILYALKER GFEQIYLVNR TKQRADNLAQ HFGKNIKVYD 190 200 210 220 230 240 WHKIHEILYQ ADLIVNTTSI GIKNPEEKSD SFFCDFHKAK KTALVTDIVY TPLITPFLQQ 250 260 270 280 290 AKSCGLKTVD GLGMLLHQAV IGFERWFGVR PQVTKALRTA ILEDMSEERE

References

[1]

"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors." Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C. Nat. Genet. 39:1469-1476(2007) [PubMed: 18037886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIP 105476 / IBS 506.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260525 Genomic DNA. Translation: CAK00508.1.
RefSeq	YP_001608503.1. NC_010161.1.
3D structure databases
ProteinModelPortal	A9IKY5.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IKY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5829772.
GenomeReviews	Gene locus BT_0003 in contig AM260525_GR.
PATRIC	20547720. VBIBarTri113218_0025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	ILEDMSE.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	BTRI382640:BT_0003-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BART1

Accession

Primary (citable) accession number: A9IKY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program