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A9IIS3

- MDH_BORPD

UniProt

A9IIS3 - MDH_BORPD

Protein

Malate dehydrogenase

Gene

mdh

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951SubstrateUniRule annotation
    Binding sitei101 – 1011SubstrateUniRule annotation
    Binding sitei108 – 1081NADUniRule annotation
    Binding sitei115 – 1151NADUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Active sitei190 – 1901Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 187NADUniRule annotation
    Nucleotide bindingi132 – 1343NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-1842-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Bpet1818
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Malate dehydrogenasePRO_1000191609Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi340100.Bpet1818.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IIS3.
    SMRiA9IIS3. Positions 3-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiNCLIASK.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9IIS3-1 [UniParc]FASTAAdd to Basket

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    MSKPAMRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEIPDEKAQ    50
    KALKGVIMEL DDCAFPLLQE VTAHSDPRTA FKDADVALLV GARPRGPGME 100
    RKDLLSVNAQ IFTAQGKALN DVASRNVKVL VVGNPANTNA YIAMKSAPDL 150
    PAKNFTAMLR LDHNRALSQL AAKSGKAVAD IEKLVVWGNH SPTMYPDYRF 200
    ATVGGQSLAK LINDDAWNRD TFIPTVGKRG AAIIEARGLS SAASAANAAI 250
    DHVRDWVLGS NGKWVTMGIP SDGSYGIPEG IIYGVPVTTE NGEYKRVEGL 300
    EIDAFSRERL DFTLKELLEE RDGVKDLLK 329
    Length:329
    Mass (Da):35,440
    Last modified:February 5, 2008 - v1
    Checksum:i505EAFF3AF09D1CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42157.1.
    RefSeqiWP_012248740.1. NC_010170.1.
    YP_001630426.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP42157; CAP42157; Bpet1818.
    GeneIDi5820459.
    KEGGibpt:Bpet1818.
    PATRICi21165089. VBIBorPet31633_1809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42157.1 .
    RefSeqi WP_012248740.1. NC_010170.1.
    YP_001630426.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9IIS3.
    SMRi A9IIS3. Positions 3-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet1818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP42157 ; CAP42157 ; Bpet1818 .
    GeneIDi 5820459.
    KEGGi bpt:Bpet1818.
    PATRICi 21165089. VBIBorPet31633_1809.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi NCLIASK.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci BPET340100:GJBO-1842-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiMDH_BORPD
    AccessioniPrimary (citable) accession number: A9IIS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3