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A9IIL7

- A9IIL7_BORPD

UniProt

A9IIL7 - A9IIL7_BORPD

Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei318 – 3181Coenzyme AUniRule annotation
    Binding sitei398 – 3981Substrate; via nitrogen amideUniRule annotation
    Binding sitei512 – 5121SubstrateUniRule annotation
    Binding sitei527 – 5271SubstrateUniRule annotation
    Active sitei529 – 5291UniRule annotation
    Binding sitei535 – 5351Coenzyme AUniRule annotation
    Binding sitei538 – 5381SubstrateUniRule annotation
    Metal bindingi549 – 5491Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi551 – 5511Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi554 – 5541Magnesium; via carbonyl oxygenUniRule annotation
    Binding sitei599 – 5991Coenzyme AUniRule annotation

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
    2. AMP binding Source: InterPro
    3. ATP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from acetate Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-1806-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
    Short name:
    AcCoA synthetaseUniRule annotation
    Short name:
    AcsUniRule annotation
    Alternative name(s):
    Acetate--CoA ligaseUniRule annotation
    Acyl-activating enzymeUniRule annotation
    Gene namesi
    Name:acsAUniRule annotation
    Ordered Locus Names:Bpet1782Imported
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)Imported
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei624 – 6241N6-acetyllysineUniRule annotation

    Post-translational modificationi

    Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

    Keywords - PTMi

    AcetylationUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi340100.Bpet1782.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IIL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni422 – 4276Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0365.
    HOGENOMiHOG000229981.
    KOiK01895.
    OMAiGGCEAVT.
    OrthoDBiEOG68WR2H.

    Family and domain databases

    HAMAPiMF_01123. Ac_CoA_synth.
    InterProiIPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9IIL7-1 [UniParc]FASTAAdd to Basket

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    MSNTIESVLV ETRVFPPPER AAQGARIGSM DAYRALCQEV EQDFDGFWTR    50
    QARENLTWSK PFTQVLDESN APFYRWFGDG ELNVSANCLD VHLNNGNADK 100
    TAIIFESDDG KVDKVTYREL LARVCRFANG LKSLGYKKGD RAIIYMPMSI 150
    QAVVAMQACA RLGVTHSVVF GGFSAKSLQE RIVDVGASLV ITADEQVRGG 200
    KTIPLKPAVE EAIGMGGCDA VTKIVVYKRT GGNVPWQDGR DLWMHDVEAG 250
    QPDTCEPVPV NAEHPLFILY TSGSTGKPKG VQHSSGGYLL WALLTVKWTF 300
    DARPDDVYWC TADVGWVTGH TYITYGPLAA GLTQIVFEGV PTYPDAGRFW 350
    DMIARHKVTT FYTAPTAIRS LIKASEATPA AHPRNYDLNS LRIIGTVGEP 400
    INPEAWVWYH KNVGQERCPI VDTWWQTETG GHMINPLPGA TPTKPGSCTL 450
    PLPGIAATVV DETGAEVEPG NGGFLAIKRP WPAMIRTIWG DPERFKKSYF 500
    PPELRGYYLA GDGAQRDADG YFWIMGRIDD VLNVSGHRLG TMEVESALVS 550
    HELVAEAAVV GRPDDTTGEA VVAFVVLKRA RPEGDEAQAI AKQLRDWVGK 600
    EIGPIAKPKD IRFGDNLPKT RSGKIMRRLL RVVAKGEQIT QDVSTLENPA 650
    ILDQLAKSV 659
    Length:659
    Mass (Da):72,328
    Last modified:February 5, 2008 - v1
    Checksum:iB9F6B19C56639FE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42121.1.
    RefSeqiWP_012248704.1. NC_010170.1.
    YP_001630390.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP42121; CAP42121; Bpet1782.
    GeneIDi5821098.
    KEGGibpt:Bpet1782.
    PATRICi21165015. VBIBorPet31633_1772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP42121.1 .
    RefSeqi WP_012248704.1. NC_010170.1.
    YP_001630390.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9IIL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet1782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP42121 ; CAP42121 ; Bpet1782 .
    GeneIDi 5821098.
    KEGGi bpt:Bpet1782.
    PATRICi 21165015. VBIBorPet31633_1772.

    Phylogenomic databases

    eggNOGi COG0365.
    HOGENOMi HOG000229981.
    KOi K01895.
    OMAi GGCEAVT.
    OrthoDBi EOG68WR2H.

    Enzyme and pathway databases

    BioCyci BPET340100:GJBO-1806-MONOMER.

    Family and domain databases

    HAMAPi MF_01123. Ac_CoA_synth.
    InterProi IPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448Imported.

    Entry informationi

    Entry nameiA9IIL7_BORPD
    AccessioniPrimary (citable) accession number: A9IIL7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3