A9IIC5 (PNCB_BORPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	Bpet1730

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]

Taxonomic identifier

340100 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000129461

Sequences

	Sequence		Length	Mass (Da)
	A9IIC5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: C0B0820213CBE36D	FASTA	391	44,836
	10 20 30 40 50 60 MIITSLLDTD LYKFSMMQVV LHHFPAAQVE YRYKCRTPGV NLRPYLDEIR AEVHALCQLR 70 80 90 100 110 120 FTEEELQYLG SLRFIKSDFV DFLGLFHLPE RCISIGEGEQ PGEIAITVAG PWLHTILFEI 130 140 150 160 170 180 PVLAIVNEVY FRNTRRHPDW DEGRQRLQSK MHLVLDDPAL ADFRVAEYGT RRRFSKLWHE 190 200 210 220 230 240 EIVSTMKAQM GAHFAGTSNV LLAMRHNVLP LGTMGHEYLQ ACQALGPRLR DSQVFALEVW 250 260 270 280 290 300 AKEYRGDLGI ALSDVYGMDA FLRDFDMYFC KLFDGARHDS GDPFVWGERL LEHYRNNRVD 310 320 330 340 350 360 PRAKTLVFSD SLTFPRAIEL ARQFAGRCKV SFGIGTNLTN DLGHEPLQIV MKMVRCNGQP 370 380 390 VAKVSDAPEK TMCDDPAYLA YLRQVFQLPP A

References

[1]

"The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae." Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H., Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F. , Mormann S., Nakunst D., Rueckert C., Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T., Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O., Martinez-Arias R. BMC Genomics 9:449-449(2008) [PubMed: 18826580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM902716 Genomic DNA. Translation: CAP42069.1.
RefSeq	YP_001630338.1. NC_010170.1.
3D structure databases
ProteinModelPortal	A9IIC5.
ModBase	Search...
Protein-protein interaction databases
STRING	A9IIC5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5820936.
GenomeReviews	Gene locus Bpet1730 in contig AM902716_GR.
KEGG	bpt:Bpet1730.
PATRIC	21164907. VBIBorPet31633_1718.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
OMA	TIGHEWI.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	BPET94624:BPET1730-MONOMER.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
KO	K00763.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BORPD

Accession

Primary (citable) accession number: A9IIC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program