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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Bpet1730
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294611 – 391Nicotinate phosphoribosyltransferaseAdd BLAST391

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet1730

Structurei

3D structure databases

ProteinModelPortaliA9IIC5
SMRiA9IIC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A9IIC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIITSLLDTD LYKFSMMQVV LHHFPAAQVE YRYKCRTPGV NLRPYLDEIR
60 70 80 90 100
AEVHALCQLR FTEEELQYLG SLRFIKSDFV DFLGLFHLPE RCISIGEGEQ
110 120 130 140 150
PGEIAITVAG PWLHTILFEI PVLAIVNEVY FRNTRRHPDW DEGRQRLQSK
160 170 180 190 200
MHLVLDDPAL ADFRVAEYGT RRRFSKLWHE EIVSTMKAQM GAHFAGTSNV
210 220 230 240 250
LLAMRHNVLP LGTMGHEYLQ ACQALGPRLR DSQVFALEVW AKEYRGDLGI
260 270 280 290 300
ALSDVYGMDA FLRDFDMYFC KLFDGARHDS GDPFVWGERL LEHYRNNRVD
310 320 330 340 350
PRAKTLVFSD SLTFPRAIEL ARQFAGRCKV SFGIGTNLTN DLGHEPLQIV
360 370 380 390
MKMVRCNGQP VAKVSDAPEK TMCDDPAYLA YLRQVFQLPP A
Length:391
Mass (Da):44,836
Last modified:February 5, 2008 - v1
Checksum:iC0B0820213CBE36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA Translation: CAP42069.1

Genome annotation databases

EnsemblBacteriaiCAP42069; CAP42069; Bpet1730
KEGGibpt:Bpet1730

Similar proteinsi

Entry informationi

Entry nameiPNCB_BORPD
AccessioniPrimary (citable) accession number: A9IIC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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