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A9IHH4

- MASZ_BORPD

UniProt

A9IHH4 - MASZ_BORPD

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Protein
Malate synthase G
Gene
glcB, Bpet4866
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi427 – 4271Magnesium By similarity
Binding sitei427 – 4271Glyoxylate By similarity
Metal bindingi455 – 4551Magnesium By similarity
Binding sitei536 – 5361Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei631 – 6311Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-4937-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Bpet4866
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Malate synthase GUniRule annotation
PRO_1000130887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei617 – 6171Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiA9IHH4.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet4866.

Structurei

3D structure databases

ProteinModelPortaliA9IHH4.
SMRiA9IHH4. Positions 2-722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni452 – 4554Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A9IHH4-1 [UniParc]FASTAAdd to Basket

« Hide

MTERIQQDGL QVAAVLHRFI QDEALPAGGI DAPRFWAGFA ALVRDLAPRN    50
RALLAERDRL QRELDTWHRA HPGPVRDLRA YRAFLEQIGY LQPVPGTVRV 100
ETANVDAEIA EQAGPQLVVP MSNARYALNA ANARWGSLYD ALYGTDAIPP 150
TPGDTGRGYH PQRGQAVIAR ARAFLDEAVP LAQGSHADAT GYSVDNGQLR 200
VALAQGSTGL AQPEQFAGYQ GDAQAPQAIL LKHHGLHIEI QIDRAHSIGA 250
TDAAGIKDVV VEAALTTIMD CEDSVAAVDA EDKVQVYRNW LGLMKGDLAE 300
QVTKGGQTFT RRLNADRVYH APGGGTLTLH GRSLMFVRNV GHLMTNPAVL 350
DADGNEIPEG ILDAVVTTLA ALPDRASRRN SRAGSIYIVK PKMHGPAEAA 400
FANELFDRVE DLLGLPRHTV KMGIMDEERR TSVNLKACIQ AAAGRVAFIN 450
TGFLDRTGDE MHSSMEAGPM MRKGDMKSSA WIAAYERSNV LVGLDCGLRG 500
RAQIGKGMWA MPDLMAAMLE QKIGHPKAGA NTAWVPSPTA ATLHALHYHQ 550
VDVPAVQQQL ESTRLASVQD ELLDGLLTVP VGNPADWSPD DIRHELENNA 600
QGILGYVVRW IDQGVGCSKV PDINNVGLME DRATLRISSQ HIANWMRHGI 650
ATREQVRDTF ERMAAVVDRQ NAGDPLYQPM AGHFDTSIAF QAACALVFEG 700
LAQPNGYTEP LLHQYRLAFK ARHNKG 726
Length:726
Mass (Da):78,962
Last modified:February 5, 2008 - v1
Checksum:i9248C75C6A1258C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP45218.1.
RefSeqiWP_012251688.1. NC_010170.1.
YP_001633485.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP45218; CAP45218; Bpet4866.
GeneIDi5819865.
KEGGibpt:Bpet4866.
PATRICi21171336. VBIBorPet31633_4894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP45218.1 .
RefSeqi WP_012251688.1. NC_010170.1.
YP_001633485.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9IHH4.
SMRi A9IHH4. Positions 2-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet4866.

Proteomic databases

PRIDEi A9IHH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP45218 ; CAP45218 ; Bpet4866 .
GeneIDi 5819865.
KEGGi bpt:Bpet4866.
PATRICi 21171336. VBIBorPet31633_4894.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci BPET340100:GJBO-4937-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiMASZ_BORPD
AccessioniPrimary (citable) accession number: A9IHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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