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A9IHH4

- MASZ_BORPD

UniProt

A9IHH4 - MASZ_BORPD

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Protein

Malate synthase G

Gene

glcB

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei274 – 2741Acetyl-CoAUniRule annotation
Binding sitei311 – 3111Acetyl-CoAUniRule annotation
Active sitei338 – 3381Proton acceptorUniRule annotation
Binding sitei338 – 3381GlyoxylateUniRule annotation
Metal bindingi427 – 4271MagnesiumUniRule annotation
Binding sitei427 – 4271GlyoxylateUniRule annotation
Metal bindingi455 – 4551MagnesiumUniRule annotation
Binding sitei536 – 5361Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei631 – 6311Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-4937-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Bpet4866
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Malate synthase GPRO_1000130887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei617 – 6171Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiA9IHH4.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet4866.

Structurei

3D structure databases

ProteinModelPortaliA9IHH4.
SMRiA9IHH4. Positions 2-722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni452 – 4554Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A9IHH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTERIQQDGL QVAAVLHRFI QDEALPAGGI DAPRFWAGFA ALVRDLAPRN
60 70 80 90 100
RALLAERDRL QRELDTWHRA HPGPVRDLRA YRAFLEQIGY LQPVPGTVRV
110 120 130 140 150
ETANVDAEIA EQAGPQLVVP MSNARYALNA ANARWGSLYD ALYGTDAIPP
160 170 180 190 200
TPGDTGRGYH PQRGQAVIAR ARAFLDEAVP LAQGSHADAT GYSVDNGQLR
210 220 230 240 250
VALAQGSTGL AQPEQFAGYQ GDAQAPQAIL LKHHGLHIEI QIDRAHSIGA
260 270 280 290 300
TDAAGIKDVV VEAALTTIMD CEDSVAAVDA EDKVQVYRNW LGLMKGDLAE
310 320 330 340 350
QVTKGGQTFT RRLNADRVYH APGGGTLTLH GRSLMFVRNV GHLMTNPAVL
360 370 380 390 400
DADGNEIPEG ILDAVVTTLA ALPDRASRRN SRAGSIYIVK PKMHGPAEAA
410 420 430 440 450
FANELFDRVE DLLGLPRHTV KMGIMDEERR TSVNLKACIQ AAAGRVAFIN
460 470 480 490 500
TGFLDRTGDE MHSSMEAGPM MRKGDMKSSA WIAAYERSNV LVGLDCGLRG
510 520 530 540 550
RAQIGKGMWA MPDLMAAMLE QKIGHPKAGA NTAWVPSPTA ATLHALHYHQ
560 570 580 590 600
VDVPAVQQQL ESTRLASVQD ELLDGLLTVP VGNPADWSPD DIRHELENNA
610 620 630 640 650
QGILGYVVRW IDQGVGCSKV PDINNVGLME DRATLRISSQ HIANWMRHGI
660 670 680 690 700
ATREQVRDTF ERMAAVVDRQ NAGDPLYQPM AGHFDTSIAF QAACALVFEG
710 720
LAQPNGYTEP LLHQYRLAFK ARHNKG
Length:726
Mass (Da):78,962
Last modified:February 5, 2008 - v1
Checksum:i9248C75C6A1258C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP45218.1.
RefSeqiWP_012251688.1. NC_010170.1.
YP_001633485.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP45218; CAP45218; Bpet4866.
GeneIDi5819865.
KEGGibpt:Bpet4866.
PATRICi21171336. VBIBorPet31633_4894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP45218.1 .
RefSeqi WP_012251688.1. NC_010170.1.
YP_001633485.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9IHH4.
SMRi A9IHH4. Positions 2-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet4866.

Proteomic databases

PRIDEi A9IHH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP45218 ; CAP45218 ; Bpet4866 .
GeneIDi 5819865.
KEGGi bpt:Bpet4866.
PATRICi 21171336. VBIBorPet31633_4894.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci BPET340100:GJBO-4937-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiMASZ_BORPD
AccessioniPrimary (citable) accession number: A9IHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3