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A9IHH4

- MASZ_BORPD

UniProt

A9IHH4 - MASZ_BORPD

Protein

Malate synthase G

Gene

glcB

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Binding sitei274 – 2741Acetyl-CoAUniRule annotation
    Binding sitei311 – 3111Acetyl-CoAUniRule annotation
    Active sitei338 – 3381Proton acceptorUniRule annotation
    Binding sitei338 – 3381GlyoxylateUniRule annotation
    Metal bindingi427 – 4271MagnesiumUniRule annotation
    Binding sitei427 – 4271GlyoxylateUniRule annotation
    Metal bindingi455 – 4551MagnesiumUniRule annotation
    Binding sitei536 – 5361Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Active sitei631 – 6311Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-HAMAP
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-4937-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Name:glcBUniRule annotation
    Ordered Locus Names:Bpet4866
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 726726Malate synthase GPRO_1000130887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei617 – 6171Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Proteomic databases

    PRIDEiA9IHH4.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi340100.Bpet4866.

    Structurei

    3D structure databases

    ProteinModelPortaliA9IHH4.
    SMRiA9IHH4. Positions 2-722.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
    Regioni452 – 4554Glyoxylate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000220740.
    KOiK01638.
    OMAiSQFIENE.
    OrthoDBiEOG6HJ286.

    Family and domain databases

    Gene3Di2.170.170.11. 2 hits.
    HAMAPiMF_00641. Malate_synth_G.
    InterProiIPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9IHH4-1 [UniParc]FASTAAdd to Basket

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    MTERIQQDGL QVAAVLHRFI QDEALPAGGI DAPRFWAGFA ALVRDLAPRN    50
    RALLAERDRL QRELDTWHRA HPGPVRDLRA YRAFLEQIGY LQPVPGTVRV 100
    ETANVDAEIA EQAGPQLVVP MSNARYALNA ANARWGSLYD ALYGTDAIPP 150
    TPGDTGRGYH PQRGQAVIAR ARAFLDEAVP LAQGSHADAT GYSVDNGQLR 200
    VALAQGSTGL AQPEQFAGYQ GDAQAPQAIL LKHHGLHIEI QIDRAHSIGA 250
    TDAAGIKDVV VEAALTTIMD CEDSVAAVDA EDKVQVYRNW LGLMKGDLAE 300
    QVTKGGQTFT RRLNADRVYH APGGGTLTLH GRSLMFVRNV GHLMTNPAVL 350
    DADGNEIPEG ILDAVVTTLA ALPDRASRRN SRAGSIYIVK PKMHGPAEAA 400
    FANELFDRVE DLLGLPRHTV KMGIMDEERR TSVNLKACIQ AAAGRVAFIN 450
    TGFLDRTGDE MHSSMEAGPM MRKGDMKSSA WIAAYERSNV LVGLDCGLRG 500
    RAQIGKGMWA MPDLMAAMLE QKIGHPKAGA NTAWVPSPTA ATLHALHYHQ 550
    VDVPAVQQQL ESTRLASVQD ELLDGLLTVP VGNPADWSPD DIRHELENNA 600
    QGILGYVVRW IDQGVGCSKV PDINNVGLME DRATLRISSQ HIANWMRHGI 650
    ATREQVRDTF ERMAAVVDRQ NAGDPLYQPM AGHFDTSIAF QAACALVFEG 700
    LAQPNGYTEP LLHQYRLAFK ARHNKG 726
    Length:726
    Mass (Da):78,962
    Last modified:February 5, 2008 - v1
    Checksum:i9248C75C6A1258C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP45218.1.
    RefSeqiWP_012251688.1. NC_010170.1.
    YP_001633485.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP45218; CAP45218; Bpet4866.
    GeneIDi5819865.
    KEGGibpt:Bpet4866.
    PATRICi21171336. VBIBorPet31633_4894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP45218.1 .
    RefSeqi WP_012251688.1. NC_010170.1.
    YP_001633485.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9IHH4.
    SMRi A9IHH4. Positions 2-722.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet4866.

    Proteomic databases

    PRIDEi A9IHH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP45218 ; CAP45218 ; Bpet4866 .
    GeneIDi 5819865.
    KEGGi bpt:Bpet4866.
    PATRICi 21171336. VBIBorPet31633_4894.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000220740.
    KOi K01638.
    OMAi SQFIENE.
    OrthoDBi EOG6HJ286.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci BPET340100:GJBO-4937-MONOMER.

    Family and domain databases

    Gene3Di 2.170.170.11. 2 hits.
    HAMAPi MF_00641. Malate_synth_G.
    InterProi IPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiMASZ_BORPD
    AccessioniPrimary (citable) accession number: A9IHH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3