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A9I7K9

- GCSP_BORPD

UniProt

A9I7K9 - GCSP_BORPD

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBPET340100:GJBO-4137-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Bpet4074
    OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
    Taxonomic identifieri340100 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001225: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000190205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi340100.Bpet4074.

    Structurei

    3D structure databases

    ProteinModelPortaliA9I7K9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9I7K9-1 [UniParc]FASTAAdd to Basket

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    MSRALDPHTD FIPRHIGPTA ADQEKMLAAI GCGSLDALLQ EVVPPAIRSQ    50
    GPLALPASRS ESDVLADLKA VAGRNRIYRN YIGQGYYGTH TPNVVLRNVL 100
    ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA 150
    AAEAMTLARR GSKSASQVFF VSAHCHPQTI EVVRTRAEGL GIEVALGDEA 200
    QGLPECFGVL LQYPHSLGGV ADYRALAEAA HAQGAVVACA TDLLALALMT 250
    PPGEWGADIA IGSSQRFGVP FGFGGPHAGF MACKDAYKRN MPGRLVGVSK 300
    DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPDG 350
    IRRIATRVHR YTAILRAALT QLGIKVVNDT FFDTLLLETG VATPAIVEAA 400
    VCEHINLRRV DGARLAVSLD ETVTAADLQA LVNVFAAGLQ KDDLALDIDA 450
    HDAAAPGGIP AALQRQGGIL AHPVFSSIQS ETDMLRYLRK LADKDLALDR 500
    SMIPLGSCTM KLNATAEMIP ITWPEFALIH PYAPADQSAG YRELIERLSK 550
    ALCEITGYDD ISLQPNSGAQ GEYAGLLAIR GYHRANGQAQ RNVCLIPASA 600
    HGTNPASAQL AGMEVVVVAS DANGNVDLDD LRAKLTQVGD RLAALMITYP 650
    STHGVFEESI THICDLVHQA GGQVYLDGAN MNAMVGVARP GKFGSDVSHL 700
    NLHKTFCIPH GGGGPGVGPV AVRSHLAPFL PGVLNAQGKL GGETGIGPVA 750
    AAPYGSAGIL PISYAYIALM GADGLRRATE VAILNANYVA ARLRDYYPVL 800
    YAGRNGRVAH ECILDVRPLK DSSGISAEDI AKRLMDYGFH APTMSFPVAG 850
    TLMVEPTESE GLAELERFID AMIAIREEIA QVERGERDRD DNVLKNAPHT 900
    AQMLLAEEWL HDYPRQQAAY PVASLRDAKY WPPVARVDNA YGDRNLVCAC 950
    LPVEAYA 957
    Length:957
    Mass (Da):102,252
    Last modified:February 5, 2008 - v1
    Checksum:iF49F609876EE9BEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP44422.1.
    RefSeqiWP_012250963.1. NC_010170.1.
    YP_001632690.1. NC_010170.1.

    Genome annotation databases

    EnsemblBacteriaiCAP44422; CAP44422; Bpet4074.
    GeneIDi5817749.
    KEGGibpt:Bpet4074.
    PATRICi21169783. VBIBorPet31633_4121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM902716 Genomic DNA. Translation: CAP44422.1 .
    RefSeqi WP_012250963.1. NC_010170.1.
    YP_001632690.1. NC_010170.1.

    3D structure databases

    ProteinModelPortali A9I7K9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340100.Bpet4074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP44422 ; CAP44422 ; Bpet4074 .
    GeneIDi 5817749.
    KEGGi bpt:Bpet4074.
    PATRICi 21169783. VBIBorPet31633_4121.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BPET340100:GJBO-4137-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

    Entry informationi

    Entry nameiGCSP_BORPD
    AccessioniPrimary (citable) accession number: A9I7K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3