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A9I7K9 (GCSP_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Bpet4074
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000190205

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A9I7K9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: F49F609876EE9BEF

FASTA957102,252
        10         20         30         40         50         60 
MSRALDPHTD FIPRHIGPTA ADQEKMLAAI GCGSLDALLQ EVVPPAIRSQ GPLALPASRS 

        70         80         90        100        110        120 
ESDVLADLKA VAGRNRIYRN YIGQGYYGTH TPNVVLRNVL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNYQTM VADLTGLDIS NASLLDEGTA AAEAMTLARR GSKSASQVFF VSAHCHPQTI 

       190        200        210        220        230        240 
EVVRTRAEGL GIEVALGDEA QGLPECFGVL LQYPHSLGGV ADYRALAEAA HAQGAVVACA 

       250        260        270        280        290        300 
TDLLALALMT PPGEWGADIA IGSSQRFGVP FGFGGPHAGF MACKDAYKRN MPGRLVGVSK 

       310        320        330        340        350        360 
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPDG IRRIATRVHR 

       370        380        390        400        410        420 
YTAILRAALT QLGIKVVNDT FFDTLLLETG VATPAIVEAA VCEHINLRRV DGARLAVSLD 

       430        440        450        460        470        480 
ETVTAADLQA LVNVFAAGLQ KDDLALDIDA HDAAAPGGIP AALQRQGGIL AHPVFSSIQS 

       490        500        510        520        530        540 
ETDMLRYLRK LADKDLALDR SMIPLGSCTM KLNATAEMIP ITWPEFALIH PYAPADQSAG 

       550        560        570        580        590        600 
YRELIERLSK ALCEITGYDD ISLQPNSGAQ GEYAGLLAIR GYHRANGQAQ RNVCLIPASA 

       610        620        630        640        650        660 
HGTNPASAQL AGMEVVVVAS DANGNVDLDD LRAKLTQVGD RLAALMITYP STHGVFEESI 

       670        680        690        700        710        720 
THICDLVHQA GGQVYLDGAN MNAMVGVARP GKFGSDVSHL NLHKTFCIPH GGGGPGVGPV 

       730        740        750        760        770        780 
AVRSHLAPFL PGVLNAQGKL GGETGIGPVA AAPYGSAGIL PISYAYIALM GADGLRRATE 

       790        800        810        820        830        840 
VAILNANYVA ARLRDYYPVL YAGRNGRVAH ECILDVRPLK DSSGISAEDI AKRLMDYGFH 

       850        860        870        880        890        900 
APTMSFPVAG TLMVEPTESE GLAELERFID AMIAIREEIA QVERGERDRD DNVLKNAPHT 

       910        920        930        940        950 
AQMLLAEEWL HDYPRQQAAY PVASLRDAKY WPPVARVDNA YGDRNLVCAC LPVEAYA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP44422.1.
RefSeqYP_001632690.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9I7K9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet4074.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP44422; CAP44422; Bpet4074.
GeneID5817749.
KEGGbpt:Bpet4074.
PATRIC21169783. VBIBorPet31633_4121.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycBPET340100:GJBO-4137-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BORPD
AccessionPrimary (citable) accession number: A9I7K9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families