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A9I7K9

- GCSP_BORPD

UniProt

A9I7K9 - GCSP_BORPD

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBPET340100:GJBO-4137-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Bpet4074
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000190205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet4074.

Structurei

3D structure databases

ProteinModelPortaliA9I7K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9I7K9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRALDPHTD FIPRHIGPTA ADQEKMLAAI GCGSLDALLQ EVVPPAIRSQ
60 70 80 90 100
GPLALPASRS ESDVLADLKA VAGRNRIYRN YIGQGYYGTH TPNVVLRNVL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA
160 170 180 190 200
AAEAMTLARR GSKSASQVFF VSAHCHPQTI EVVRTRAEGL GIEVALGDEA
210 220 230 240 250
QGLPECFGVL LQYPHSLGGV ADYRALAEAA HAQGAVVACA TDLLALALMT
260 270 280 290 300
PPGEWGADIA IGSSQRFGVP FGFGGPHAGF MACKDAYKRN MPGRLVGVSK
310 320 330 340 350
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPDG
360 370 380 390 400
IRRIATRVHR YTAILRAALT QLGIKVVNDT FFDTLLLETG VATPAIVEAA
410 420 430 440 450
VCEHINLRRV DGARLAVSLD ETVTAADLQA LVNVFAAGLQ KDDLALDIDA
460 470 480 490 500
HDAAAPGGIP AALQRQGGIL AHPVFSSIQS ETDMLRYLRK LADKDLALDR
510 520 530 540 550
SMIPLGSCTM KLNATAEMIP ITWPEFALIH PYAPADQSAG YRELIERLSK
560 570 580 590 600
ALCEITGYDD ISLQPNSGAQ GEYAGLLAIR GYHRANGQAQ RNVCLIPASA
610 620 630 640 650
HGTNPASAQL AGMEVVVVAS DANGNVDLDD LRAKLTQVGD RLAALMITYP
660 670 680 690 700
STHGVFEESI THICDLVHQA GGQVYLDGAN MNAMVGVARP GKFGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGVGPV AVRSHLAPFL PGVLNAQGKL GGETGIGPVA
760 770 780 790 800
AAPYGSAGIL PISYAYIALM GADGLRRATE VAILNANYVA ARLRDYYPVL
810 820 830 840 850
YAGRNGRVAH ECILDVRPLK DSSGISAEDI AKRLMDYGFH APTMSFPVAG
860 870 880 890 900
TLMVEPTESE GLAELERFID AMIAIREEIA QVERGERDRD DNVLKNAPHT
910 920 930 940 950
AQMLLAEEWL HDYPRQQAAY PVASLRDAKY WPPVARVDNA YGDRNLVCAC

LPVEAYA
Length:957
Mass (Da):102,252
Last modified:February 5, 2008 - v1
Checksum:iF49F609876EE9BEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP44422.1.
RefSeqiWP_012250963.1. NC_010170.1.
YP_001632690.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP44422; CAP44422; Bpet4074.
GeneIDi5817749.
KEGGibpt:Bpet4074.
PATRICi21169783. VBIBorPet31633_4121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP44422.1 .
RefSeqi WP_012250963.1. NC_010170.1.
YP_001632690.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9I7K9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet4074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP44422 ; CAP44422 ; Bpet4074 .
GeneIDi 5817749.
KEGGi bpt:Bpet4074.
PATRICi 21169783. VBIBorPet31633_4121.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BPET340100:GJBO-4137-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiGCSP_BORPD
AccessioniPrimary (citable) accession number: A9I7K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3