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A9I714 (HGD_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:Bpet4016
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_1000119839

Sites

Metal binding3291Iron By similarity
Metal binding3351Iron By similarity
Metal binding3651Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A9I714 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 013EFAE670C12244

FASTA43247,513
        10         20         30         40         50         60 
MPLQYQSGFG NDWATEALPG ALPAGRNSPQ RCPYGLYAEQ LSGTAFTAPR AENRRSWLYR 

        70         80         90        100        110        120 
IRPAAQHRPF EPFDGAARWL SDFGAAPVTP NQLRWSPLPL PDAPTDFIEG VQTWGGNGGP 

       130        140        150        160        170        180 
GEHGGVGIHL YAANRSMQGR YFYNADGELL IVPQQGRLRL ATELGIIEVE PLEIAVIPRG 

       190        200        210        220        230        240 
VRLRVDLPDG QARGYMLENF GAALHLPELG PIGSNCLANA RDFQTPVACY EDIEGDFELI 

       250        260        270        280        290        300 
AKFTGGFWRA AIGHSPLDVV AWHGTHAPYK YDLRHFNTIG SISFDHPDPS IFTVLTSPSD 

       310        320        330        340        350        360 
TPGTANMDFA IFPPRVLAME NTFRPPWFHR NVASEFMGLI HGVYDAKAEG FAPGGASLHN 

       370        380        390        400        410        420 
CMSGHGPDAD TFEKATAADT SQAHYIRDTM AFMFETRRVI RPTAQALASA QLQSDYYECW 

       430 
QGLNKHFDPA QP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP44364.1.
RefSeqYP_001632632.1. NC_010170.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet4016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP44364; CAP44364; Bpet4016.
GeneID5817094.
KEGGbpt:Bpet4016.
PATRIC21169657. VBIBorPet31633_4058.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycBPET340100:GJBO-4079-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_BORPD
AccessionPrimary (citable) accession number: A9I714
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways