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A9I714

- HGD_BORPD

UniProt

A9I714 - HGD_BORPD

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861Proton acceptorUniRule annotation
Metal bindingi329 – 3291IronUniRule annotation
Metal bindingi335 – 3351IronUniRule annotation
Binding sitei344 – 3441homogentisateUniRule annotation
Metal bindingi365 – 3651IronUniRule annotation
Binding sitei365 – 3651homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-4079-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:Bpet4016
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Homogentisate 1,2-dioxygenasePRO_1000119839Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet4016.

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9I714-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLQYQSGFG NDWATEALPG ALPAGRNSPQ RCPYGLYAEQ LSGTAFTAPR
60 70 80 90 100
AENRRSWLYR IRPAAQHRPF EPFDGAARWL SDFGAAPVTP NQLRWSPLPL
110 120 130 140 150
PDAPTDFIEG VQTWGGNGGP GEHGGVGIHL YAANRSMQGR YFYNADGELL
160 170 180 190 200
IVPQQGRLRL ATELGIIEVE PLEIAVIPRG VRLRVDLPDG QARGYMLENF
210 220 230 240 250
GAALHLPELG PIGSNCLANA RDFQTPVACY EDIEGDFELI AKFTGGFWRA
260 270 280 290 300
AIGHSPLDVV AWHGTHAPYK YDLRHFNTIG SISFDHPDPS IFTVLTSPSD
310 320 330 340 350
TPGTANMDFA IFPPRVLAME NTFRPPWFHR NVASEFMGLI HGVYDAKAEG
360 370 380 390 400
FAPGGASLHN CMSGHGPDAD TFEKATAADT SQAHYIRDTM AFMFETRRVI
410 420 430
RPTAQALASA QLQSDYYECW QGLNKHFDPA QP
Length:432
Mass (Da):47,513
Last modified:February 5, 2008 - v1
Checksum:i013EFAE670C12244
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP44364.1.
RefSeqiWP_012250905.1. NC_010170.1.
YP_001632632.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP44364; CAP44364; Bpet4016.
GeneIDi5817094.
KEGGibpt:Bpet4016.
PATRICi21169657. VBIBorPet31633_4058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP44364.1 .
RefSeqi WP_012250905.1. NC_010170.1.
YP_001632632.1. NC_010170.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet4016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP44364 ; CAP44364 ; Bpet4016 .
GeneIDi 5817094.
KEGGi bpt:Bpet4016.
PATRICi 21169657. VBIBorPet31633_4058.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci BPET340100:GJBO-4079-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiHGD_BORPD
AccessioniPrimary (citable) accession number: A9I714
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3