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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei286Proton acceptorUniRule annotation1
Metal bindingi329IronUniRule annotation1
Metal bindingi335IronUniRule annotation1
Binding sitei344homogentisateUniRule annotation1
Metal bindingi365IronUniRule annotation1
Binding sitei365homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:Bpet4016
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001225 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001198391 – 432Homogentisate 1,2-dioxygenaseAdd BLAST432

Proteomic databases

PRIDEiA9I714

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi340100.Bpet4016

Structurei

3D structure databases

SMRiA9I714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
KOiK00451
OMAiHGNYTPY
OrthoDBiPOG091H04E0

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

A9I714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLQYQSGFG NDWATEALPG ALPAGRNSPQ RCPYGLYAEQ LSGTAFTAPR
60 70 80 90 100
AENRRSWLYR IRPAAQHRPF EPFDGAARWL SDFGAAPVTP NQLRWSPLPL
110 120 130 140 150
PDAPTDFIEG VQTWGGNGGP GEHGGVGIHL YAANRSMQGR YFYNADGELL
160 170 180 190 200
IVPQQGRLRL ATELGIIEVE PLEIAVIPRG VRLRVDLPDG QARGYMLENF
210 220 230 240 250
GAALHLPELG PIGSNCLANA RDFQTPVACY EDIEGDFELI AKFTGGFWRA
260 270 280 290 300
AIGHSPLDVV AWHGTHAPYK YDLRHFNTIG SISFDHPDPS IFTVLTSPSD
310 320 330 340 350
TPGTANMDFA IFPPRVLAME NTFRPPWFHR NVASEFMGLI HGVYDAKAEG
360 370 380 390 400
FAPGGASLHN CMSGHGPDAD TFEKATAADT SQAHYIRDTM AFMFETRRVI
410 420 430
RPTAQALASA QLQSDYYECW QGLNKHFDPA QP
Length:432
Mass (Da):47,513
Last modified:February 5, 2008 - v1
Checksum:i013EFAE670C12244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA Translation: CAP44364.1

Genome annotation databases

EnsemblBacteriaiCAP44364; CAP44364; Bpet4016
KEGGibpt:Bpet4016

Similar proteinsi

Entry informationi

Entry nameiHGD_BORPD
AccessioniPrimary (citable) accession number: A9I714
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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