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A9I4V9 (DDL_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Bpet0699
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341061

Regions

Domain114 – 313200ATP-grasp
Nucleotide binding140 – 19556ATP By similarity

Sites

Metal binding2671Magnesium or manganese 1 By similarity
Metal binding2801Magnesium or manganese 1 By similarity
Metal binding2801Magnesium or manganese 2 By similarity
Metal binding2821Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A9I4V9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: A06ECB789068E9BB

FASTA32634,675
        10         20         30         40         50         60 
MNQSVTRPRP DAKALGKVGV LYGGRSAERD VSLMSGKGVH QALLSAGVDA HLFDTGERTL 

        70         80         90        100        110        120 
AELAAAGFDR VFIALHGRYG EDGTLQGALE LLGLPYTGSG PMASSLSMDK IMTKRVWLQH 

       130        140        150        160        170        180 
GLRTPAFEVL DAQAELRTVP DRLGLPLILK PPHEGSTVGI TKVAGYSDMK EGYAQAAKFD 

       190        200        210        220        230        240 
DEVLAEQFIA GRELTVAVLG TGAAAHALPV IEIVAPGGNY DYEHKYFSDE TQYFCPADLP 

       250        260        270        280        290        300 
DAVAAEVADL AVRAYRALGC AGWGRIDFML DADNRPWLLE ANTSPGMTSH SLVPMAAKAI 

       310        320 
GMSYAELCVS IVSEAACKVH SPARNS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP41031.1.
RefSeqYP_001629302.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9I4V9.
SMRA9I4V9. Positions 16-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet0699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP41031; CAP41031; Bpet0699.
GeneID5819505.
KEGGbpt:Bpet0699.
PATRIC21162865. VBIBorPet31633_0705.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycBPET340100:GJBO-708-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_BORPD
AccessionPrimary (citable) accession number: A9I4V9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways