A9I1U7 (AROE_BORPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Bpet0567

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]

Taxonomic identifier

340100 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100105
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A9I1U7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 6631AF446B7C689C	FASTA	287	29,545
	10 20 30 40 50 60 MSQASPLPRY AVIGNPVAHS RSPQIHAMFS SQTGKPLQYE RLLAPVDGFA ATVQAFREQG 70 80 90 100 110 120 GLGLNVTVPF KEEACQLAGA HLSERARLAG AVNTLWLRDG AWHGCNTDGV GLVSDLLRLG 130 140 150 160 170 180 VVLEGARVLL VGAGGAARGV LQPLAAAGCA RIHIVNRSAQ RAHDLAAGWA AAGAVPGTRV 190 200 210 220 230 240 TAGALAEAGV AGGWNVVVNA TASSLQGAAP ELPRGLYAPD ALAYDMMYAA HPTAFMRQAT 250 260 270 280 DDGAARTADG LGMLVGQAAE SFLIWHGVRP DPSPVLTALR ATLLAKD

References

[1]

"The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae." Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H., Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F. , Mormann S., Nakunst D., Rueckert C., Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T., Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O., Martinez-Arias R. BMC Genomics 9:449-449(2008) [PubMed: 18826580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM902716 Genomic DNA. Translation: CAP40899.1.
RefSeq	YP_001629170.1. NC_010170.1.
3D structure databases
ProteinModelPortal	A9I1U7.
ModBase	Search...
Protein-protein interaction databases
STRING	A9I1U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5819498.
GenomeReviews	Gene locus Bpet0567 in contig AM902716_GR.
KEGG	bpt:Bpet0567.
PATRIC	21162591. VBIBorPet31633_0575.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	FWRGVRP.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	BPET94624:BPET0567-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BORPD

Accession

Primary (citable) accession number: A9I1U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program