Reviewed, UniProtKB/Swiss-Prot A9HY51 (DCUP_BORPD)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Bpet0346

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]

Taxonomic identifier

340100 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000099974
Regions
	Region	29 – 33	5	Substrate binding By similarity
Sites
	Binding site	79	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	330	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9HY51-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: E97E7679AD2FDD31	FASTA	358	39,043
	10 20 30 40 50 60 MSAAALKNDV FLRALLRQPV PYTPIWLMRQ AGRYLPEYNA TRARAGSFMG LAQNPDYAAE 70 80 90 100 110 120 VTLQPLARYD LDAAILFSDI LTVPHAMGLG LDFAPGEGPR FARPLRTEDD VARLAVPDME 130 140 150 160 170 180 SLRYVFDAVA VIRRELDGKV PLIGFAGSPW TIACYMVEGR GSDDYRLIKT MLYARPDLLH 190 200 210 220 230 240 RILEVNAQAT LQYLNAQIQA GAQAVMLFDS WGGVLADGLF QQFSLAYTRK VVAGLIREHQ 250 260 270 280 290 300 GRRVPAIVFT KGGGQWLEAI AACGCDAIGL DWTVNLGQAR QRTGDAVALQ GNLDPMTLFG 310 320 330 340 350 GSEAIRAEAR RTLDAFGPVG TGGHVFNLGH GISQYTPPEA VAELVDEVHT YSRALHAK

References

[1]

"The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae." Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H., Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F. , Mormann S., Nakunst D., Rueckert C., Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T., Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O., Martinez-Arias R. BMC Genomics 9:449-449(2008) [PubMed: 18826580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM902716 Genomic DNA. Translation: CAP40678.1.
RefSeq	YP_001628949.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5818596.
GenomeReviews	Gene locus Bpet0346 in contig AM902716_GR.
KEGG	bpt:Bpet0346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VFTKGGG.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BORPD

Accession

Primary (citable) accession number: A9HY51

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)