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A9HWW6

- SYL_BORPD

UniProt

A9HWW6 - SYL_BORPD

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Protein
Leucine--tRNA ligase
Gene
leuS, Bpet3324
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei642 – 6421ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Bpet3324
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligaseUniRule annotation
PRO_0000334733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet3324.

Structurei

3D structure databases

ProteinModelPortaliA9HWW6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi639 – 6435"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HWW6-1 [UniParc]FASTAAdd to Basket

« Hide

MQERYSPTAV EAAAQQDWQA RDAYRVTEHA RNADGTEKPK FYACSMLPYP    50
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK 100
VPPAKWTYDN IAYMKKQMQA MGLAIDWSRE MCACDPEYYK WNQWLFLKML 150
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLR 200
ITDYADELLD QVRSGLPGWP ERVRAMQENW IGKSEGVRFA FPHTIAGADG 250
QLIQDGRLYV FTTRADTIMG VTFCAVAPEH PLATHAAATN PELASFIEQC 300
KLGGTTEAEI ATREKAGMRT GLTVTHPLTG APVDVWVGNY VLMSYGDGAV 350
MGVPAHDERD FAFAKKYQLP IRQVVAHEGK AYSTDAWQEW YGDKQGGRTV 400
NSGKYDGLPY AEAVDAIAAD LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI 450
PIIHCADCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPRCG 500
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDARNDYW MPMDQYIGGI 550
EHAVLHLLYA RFWTRVMRDL GLLKFDEPFT KLLCQGMVLN HIYSRKNAQG 600
GIEYFWPEEV ENLYDAKGAI TGARLKSDGS DVNYGGVGTM SKSKNNGVDP 650
QALIDTLGAD TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWSHCHAH 700
RDAVARGLAA GADWAQAPAP VKDLRREVYG LLKQADYDYQ RIQYNTVVSA 750
CMKMLNAIDD AKLPEGAHAD AARAETLGVL LRVLYPVVPH VTWLLWRELG 800
YTHSLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGAI RVAAKASKAD 850
IEQIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG 885
Length:885
Mass (Da):98,772
Last modified:February 5, 2008 - v1
Checksum:iDF3BBA0AF1F0EFE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1.
RefSeqiWP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP43666; CAP43666; Bpet3324.
GeneIDi5820914.
KEGGibpt:Bpet3324.
PATRICi21168223. VBIBorPet31633_3357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1 .
RefSeqi WP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9HWW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet3324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP43666 ; CAP43666 ; Bpet3324 .
GeneIDi 5820914.
KEGGi bpt:Bpet3324.
PATRICi 21168223. VBIBorPet31633_3357.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BPET340100:GJBO-3366-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiSYL_BORPD
AccessioniPrimary (citable) accession number: A9HWW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi