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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei642 – 6421ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bpet3324
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligasePRO_0000334733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet3324.

Structurei

3D structure databases

ProteinModelPortaliA9HWW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi639 – 6435"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HWW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERYSPTAV EAAAQQDWQA RDAYRVTEHA RNADGTEKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMQA MGLAIDWSRE MCACDPEYYK WNQWLFLKML
160 170 180 190 200
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLR
210 220 230 240 250
ITDYADELLD QVRSGLPGWP ERVRAMQENW IGKSEGVRFA FPHTIAGADG
260 270 280 290 300
QLIQDGRLYV FTTRADTIMG VTFCAVAPEH PLATHAAATN PELASFIEQC
310 320 330 340 350
KLGGTTEAEI ATREKAGMRT GLTVTHPLTG APVDVWVGNY VLMSYGDGAV
360 370 380 390 400
MGVPAHDERD FAFAKKYQLP IRQVVAHEGK AYSTDAWQEW YGDKQGGRTV
410 420 430 440 450
NSGKYDGLPY AEAVDAIAAD LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCADCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPRCG
510 520 530 540 550
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDARNDYW MPMDQYIGGI
560 570 580 590 600
EHAVLHLLYA RFWTRVMRDL GLLKFDEPFT KLLCQGMVLN HIYSRKNAQG
610 620 630 640 650
GIEYFWPEEV ENLYDAKGAI TGARLKSDGS DVNYGGVGTM SKSKNNGVDP
660 670 680 690 700
QALIDTLGAD TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWSHCHAH
710 720 730 740 750
RDAVARGLAA GADWAQAPAP VKDLRREVYG LLKQADYDYQ RIQYNTVVSA
760 770 780 790 800
CMKMLNAIDD AKLPEGAHAD AARAETLGVL LRVLYPVVPH VTWLLWRELG
810 820 830 840 850
YTHSLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGAI RVAAKASKAD
860 870 880
IEQIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG
Length:885
Mass (Da):98,772
Last modified:February 5, 2008 - v1
Checksum:iDF3BBA0AF1F0EFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1.
RefSeqiWP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP43666; CAP43666; Bpet3324.
KEGGibpt:Bpet3324.
PATRICi21168223. VBIBorPet31633_3357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1.
RefSeqiWP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

3D structure databases

ProteinModelPortaliA9HWW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340100.Bpet3324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP43666; CAP43666; Bpet3324.
KEGGibpt:Bpet3324.
PATRICi21168223. VBIBorPet31633_3357.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3366-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiSYL_BORPD
AccessioniPrimary (citable) accession number: A9HWW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.