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A9HWW6

- SYL_BORPD

UniProt

A9HWW6 - SYL_BORPD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei642 – 6421ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPET340100:GJBO-3366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bpet3324
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001225: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligasePRO_0000334733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet3324.

Structurei

3D structure databases

ProteinModelPortaliA9HWW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi639 – 6435"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HWW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQERYSPTAV EAAAQQDWQA RDAYRVTEHA RNADGTEKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMQA MGLAIDWSRE MCACDPEYYK WNQWLFLKML
160 170 180 190 200
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLR
210 220 230 240 250
ITDYADELLD QVRSGLPGWP ERVRAMQENW IGKSEGVRFA FPHTIAGADG
260 270 280 290 300
QLIQDGRLYV FTTRADTIMG VTFCAVAPEH PLATHAAATN PELASFIEQC
310 320 330 340 350
KLGGTTEAEI ATREKAGMRT GLTVTHPLTG APVDVWVGNY VLMSYGDGAV
360 370 380 390 400
MGVPAHDERD FAFAKKYQLP IRQVVAHEGK AYSTDAWQEW YGDKQGGRTV
410 420 430 440 450
NSGKYDGLPY AEAVDAIAAD LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCADCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPRCG
510 520 530 540 550
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDARNDYW MPMDQYIGGI
560 570 580 590 600
EHAVLHLLYA RFWTRVMRDL GLLKFDEPFT KLLCQGMVLN HIYSRKNAQG
610 620 630 640 650
GIEYFWPEEV ENLYDAKGAI TGARLKSDGS DVNYGGVGTM SKSKNNGVDP
660 670 680 690 700
QALIDTLGAD TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWSHCHAH
710 720 730 740 750
RDAVARGLAA GADWAQAPAP VKDLRREVYG LLKQADYDYQ RIQYNTVVSA
760 770 780 790 800
CMKMLNAIDD AKLPEGAHAD AARAETLGVL LRVLYPVVPH VTWLLWRELG
810 820 830 840 850
YTHSLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGAI RVAAKASKAD
860 870 880
IEQIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG
Length:885
Mass (Da):98,772
Last modified:February 5, 2008 - v1
Checksum:iDF3BBA0AF1F0EFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1.
RefSeqiWP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

Genome annotation databases

EnsemblBacteriaiCAP43666; CAP43666; Bpet3324.
GeneIDi5820914.
KEGGibpt:Bpet3324.
PATRICi21168223. VBIBorPet31633_3357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA. Translation: CAP43666.1 .
RefSeqi WP_012250223.1. NC_010170.1.
YP_001631934.1. NC_010170.1.

3D structure databases

ProteinModelPortali A9HWW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340100.Bpet3324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP43666 ; CAP43666 ; Bpet3324 .
GeneIDi 5820914.
KEGGi bpt:Bpet3324.
PATRICi 21168223. VBIBorPet31633_3357.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BPET340100:GJBO-3366-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-461 / DSM 12804 / CCUG 43448.

Entry informationi

Entry nameiSYL_BORPD
AccessioniPrimary (citable) accession number: A9HWW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3