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A9HWW6 (SYL_BORPD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Bpet3324
OrganismBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) [Complete proteome] [HAMAP]
Taxonomic identifier340100 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334733

Regions

Motif48 – 5811"HIGH" region HAMAP-Rule MF_00049
Motif639 – 6435"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9HWW6 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: DF3BBA0AF1F0EFE2

FASTA88598,772
        10         20         30         40         50         60 
MQERYSPTAV EAAAQQDWQA RDAYRVTEHA RNADGTEKPK FYACSMLPYP SGKLHMGHVR 

        70         80         90        100        110        120 
NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK VPPAKWTYDN IAYMKKQMQA 

       130        140        150        160        170        180 
MGLAIDWSRE MCACDPEYYK WNQWLFLKML EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG 

       190        200        210        220        230        240 
RGWRSGALVE KREIPGYYLR ITDYADELLD QVRSGLPGWP ERVRAMQENW IGKSEGVRFA 

       250        260        270        280        290        300 
FPHTIAGADG QLIQDGRLYV FTTRADTIMG VTFCAVAPEH PLATHAAATN PELASFIEQC 

       310        320        330        340        350        360 
KLGGTTEAEI ATREKAGMRT GLTVTHPLTG APVDVWVGNY VLMSYGDGAV MGVPAHDERD 

       370        380        390        400        410        420 
FAFAKKYQLP IRQVVAHEGK AYSTDAWQEW YGDKQGGRTV NSGKYDGLPY AEAVDAIAAD 

       430        440        450        460        470        480 
LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI PIIHCADCGP VPVPEQDLPV VLPDDLIPDG 

       490        500        510        520        530        540 
SGNPLAKNEA FLSCSCPRCG KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDARNDYW 

       550        560        570        580        590        600 
MPMDQYIGGI EHAVLHLLYA RFWTRVMRDL GLLKFDEPFT KLLCQGMVLN HIYSRKNAQG 

       610        620        630        640        650        660 
GIEYFWPEEV ENLYDAKGAI TGARLKSDGS DVNYGGVGTM SKSKNNGVDP QALIDTLGAD 

       670        680        690        700        710        720 
TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWSHCHAH RDAVARGLAA GADWAQAPAP 

       730        740        750        760        770        780 
VKDLRREVYG LLKQADYDYQ RIQYNTVVSA CMKMLNAIDD AKLPEGAHAD AARAETLGVL 

       790        800        810        820        830        840 
LRVLYPVVPH VTWLLWRELG YTHSLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGAI 

       850        860        870        880 
RVAAKASKAD IEQIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM902716 Genomic DNA. Translation: CAP43666.1.
RefSeqYP_001631934.1. NC_010170.1.

3D structure databases

ProteinModelPortalA9HWW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340100.Bpet3324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP43666; CAP43666; Bpet3324.
GeneID5820914.
KEGGbpt:Bpet3324.
PATRIC21168223. VBIBorPet31633_3357.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBPET340100:GJBO-3366-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BORPD
AccessionPrimary (citable) accession number: A9HWW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries