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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei642ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bpet3324
OrganismiBordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Taxonomic identifieri340100 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001225 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347331 – 885Leucine--tRNA ligaseAdd BLAST885

Proteomic databases

PRIDEiA9HWW6

Interactioni

Protein-protein interaction databases

STRINGi340100.Bpet3324

Structurei

3D structure databases

ProteinModelPortaliA9HWW6
SMRiA9HWW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 58"HIGH" regionAdd BLAST11
Motifi639 – 643"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9HWW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERYSPTAV EAAAQQDWQA RDAYRVTEHA RNADGTEKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMQA MGLAIDWSRE MCACDPEYYK WNQWLFLKML
160 170 180 190 200
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLR
210 220 230 240 250
ITDYADELLD QVRSGLPGWP ERVRAMQENW IGKSEGVRFA FPHTIAGADG
260 270 280 290 300
QLIQDGRLYV FTTRADTIMG VTFCAVAPEH PLATHAAATN PELASFIEQC
310 320 330 340 350
KLGGTTEAEI ATREKAGMRT GLTVTHPLTG APVDVWVGNY VLMSYGDGAV
360 370 380 390 400
MGVPAHDERD FAFAKKYQLP IRQVVAHEGK AYSTDAWQEW YGDKQGGRTV
410 420 430 440 450
NSGKYDGLPY AEAVDAIAAD LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCADCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPRCG
510 520 530 540 550
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDARNDYW MPMDQYIGGI
560 570 580 590 600
EHAVLHLLYA RFWTRVMRDL GLLKFDEPFT KLLCQGMVLN HIYSRKNAQG
610 620 630 640 650
GIEYFWPEEV ENLYDAKGAI TGARLKSDGS DVNYGGVGTM SKSKNNGVDP
660 670 680 690 700
QALIDTLGAD TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWSHCHAH
710 720 730 740 750
RDAVARGLAA GADWAQAPAP VKDLRREVYG LLKQADYDYQ RIQYNTVVSA
760 770 780 790 800
CMKMLNAIDD AKLPEGAHAD AARAETLGVL LRVLYPVVPH VTWLLWRELG
810 820 830 840 850
YTHSLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGAI RVAAKASKAD
860 870 880
IEQIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG
Length:885
Mass (Da):98,772
Last modified:February 5, 2008 - v1
Checksum:iDF3BBA0AF1F0EFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM902716 Genomic DNA Translation: CAP43666.1

Genome annotation databases

EnsemblBacteriaiCAP43666; CAP43666; Bpet3324
KEGGibpt:Bpet3324

Similar proteinsi

Entry informationi

Entry nameiSYL_BORPD
AccessioniPrimary (citable) accession number: A9HWW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health