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A9HS56 (A9HS56_GLUDA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase large subunit HAMAP-Rule MF_01026
EC=4.2.1.33 HAMAP-Rule MF_01026
Alternative name(s):
Alpha-IPM isomerase HAMAP-Rule MF_01026
Isopropylmalate isomerase HAMAP-Rule MF_01026
Gene names
Name:leuC HAMAP-Rule MF_01026 EMBL CAP57030.1
Ordered Locus Names:GDI3087 EMBL CAP57030.1
OrganismGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP] EMBL CAP57030.1
Taxonomic identifier272568 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter ›

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. HAMAP-Rule MF_01026 SAAS SAAS004430

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. HAMAP-Rule MF_01026

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP-Rule MF_01026 SAAS SAAS015931

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP-Rule MF_01026 SAAS SAAS004430

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP-Rule MF_01026 SAAS SAAS004430

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. HAMAP-Rule MF_01026

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding3641Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_01026
Metal binding4241Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_01026
Metal binding4271Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_01026

Sequences

Sequence LengthMass (Da)Tools
A9HS56 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 6BBA908F455426E9

FASTA48351,912
        10         20         30         40         50         60 
MAALAYPMTK RKEERPMAAR TLFDKIWDSH VVERLEDGTA ILYIDRHLVH EVTSPQAFEG 

        70         80         90        100        110        120 
LRASGRRLRR PDATIAVVDH NVPTSDRTRP IEEPESRNQV ETLERNVREF GVPYFPLLSE 

       130        140        150        160        170        180 
RQGIVHVVGP EQGISLPGMT IVCGDSHTST HGALGALAFG IGTSEVEHVM ATQTLLQKPA 

       190        200        210        220        230        240 
RNMKVVVEGP LGAGVTAKDV MLAIIGRIGT AGGTGHVIEF AGSTIRGLDM AGRMTICNMA 

       250        260        270        280        290        300 
IEAGARAGLV APDQTTFDYV RGRPFAPQGE AFDQAVAWWK TLPADEGAQY DKVVELRAED 

       310        320        330        340        350        360 
IPPVLTWGTS PETVIPVTGT VPDPQAEPDE ARRGQMRRML DYMGLQAGQP IAGVPVDVVF 

       370        380        390        400        410        420 
IGSCTNSRIE DLRSAAAVVA GRHVAPGVRA MVVPGSGIVK AQAEQEGLDR IFRDAGFEWR 

       430        440        450        460        470        480 
EAGCSMCLGM NPDKLTPGQR CASTSNRNFE GRQGPGGRTH LLSPAMAAAA AVTGHLTDVR 


ELI

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References

[1]"Gluconacetobacter diazotrophicus Pal5 complete genome."
Bertalan M., Baldani I.J., Ferreira P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49037 / DSM 5601 / PAl5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM889285 Genomic DNA. Translation: CAP57030.1.
RefSeqYP_001603319.1. NC_010125.1.

3D structure databases

ProteinModelPortalA9HS56.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP57030; CAP57030; GDI3087.
GeneID5791916.
KEGGgdi:GDI_3087.
PATRIC22061592. VBIGluDia122154_2938.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01703.
OMADIRQGIV.
ProtClustDBPRK05478.

Enzyme and pathway databases

BioCycGDIA272568:GJPS-3141-MONOMER.
UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
HAMAPMF_01026. LeuC_type1.
InterProIPR004430. 3-IsopropMal_deHydase_lsu.
IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PfamPF00330. Aconitase. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR00170. leuC. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9HS56_GLUDA
AccessionPrimary (citable) accession number: A9HS56
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info