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A9HS28 (A9HS28_GLUDA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH EMBL CAP57018.1
Synonyms:fabH1 HAMAP MF_01815
Ordered Locus Names:GDI3075
OrganismGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP]
Taxonomic identifier272568 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region269 – 2735ACP-binding By similarity HAMAP MF_01815

Sites

Active site1291 By similarity HAMAP MF_01815
Active site2681 By similarity HAMAP MF_01815
Active site2981 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A9HS28 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 660D7A0F32697C2E

FASTA34135,854
        10         20         30         40         50         60 
MRRVGSGAGF GMMGMMARRS LLVGFGGYLP DRIVTNDELA ARLETSDEWI RARTGITQRH 

        70         80         90        100        110        120 
IAGPHDTAVS MAAAAGARAL DYAGMAAADV GAIIVATSTP DQAFPSTAVR VQAELGLRGG 

       130        140        150        160        170        180 
FGFDIAAACS GFVYALSMAD SLIRSGQVDS VLVIGSEVYS RILDWSDRGT CVLFGDGAGA 

       190        200        210        220        230        240 
VLLKAADGPE PGDTRPKGIL STHLHSDGST GDLLYVDGAI GLRESSGFLR MRGRDVFRHA 

       250        260        270        280        290        300 
VAKLSSSVDE VLHANGLTYA DVNWLVPHQA NLRIIEGVAR KLELPPERVV VTVDRHANTS 

       310        320        330        340 
AASIPLAMNE AVRDGRIRPG DLVLMEALGG GLTWGSALAR M

« Hide

References

[1]"Gluconacetobacter diazotrophicus Pal5 complete genome."
Bertalan M., Baldani I.J., Ferreira P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49037 / DSM 5601 / PAl5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM889285 Genomic DNA. Translation: CAP57018.1.
RefSeqYP_001603307.1. NC_010125.1.

3D structure databases

ProteinModelPortalA9HS28.
SMRA9HS28. Positions 22-340.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9HS28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5791904.
GenomeReviewsGene locus GDI3075 in contig AM889285_GR.
KEGGgdi:GDI_3075.
PATRIC22061566. VBIGluDia122154_2925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAVIGSEVY.
ProtClustDBCLSK935911.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9HS28_GLUDA
AccessionPrimary (citable) accession number: A9HS28
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info