A9HJG3 (A9HJG3_GLUDA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
EC=6.3.5.3 HAMAP-Rule MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420

Gene names

Name:	purL HAMAP-Rule MF_00420 EMBL CAP55903.1
Ordered Locus Names:	GDI1960 EMBL CAP55903.1

Organism

Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP] EMBL CAP55903.1

Taxonomic identifier

272568 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter › Gluconacetobacter diazotrophicus

Protein attributes

Sequence length	737 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP-Rule MF_00420
Cellular component	Cytoplasm HAMAP-Rule MF_00420
Ligand	ATP-binding HAMAP-Rule MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_00420
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	108 – 119	12	ATP By similarity HAMAP-Rule MF_00420

Sequences

	Sequence		Length	Mass (Da)
	A9HJG3 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: B2AC151E0A665F73	FASTA	737	77,704
	10 20 30 40 50 60 MSSEKGQRPV DQDLAKEFGL TAEEYGNVLS IMGRTPSLTE LGIFSVMWSE HCSYKSSRVW 70 80 90 100 110 120 LKTLPTTAPW VIHGPGENAG VVDIGQGLAA IFKMESHNHP SFIEPYQGAA TGVGGILRDV 130 140 150 160 170 180 FTMGARPVAN LNALRFGSPE NPQTRRIVDG VVRGVGGYGN CVGVPTVGGE INFHPSYDGN 190 200 210 220 230 240 PLVNAMTVGI ARQDRIFLSA AAGVGNPVIY VGSKTGRDGI HGATMSSSEF DEDALAKRPT 250 260 270 280 290 300 VQVGDPFVEK LLIEACLELM ATDAIVAIQD MGAAGLTSSS VEMAGKGGVG IDLDLDAVPQ 310 320 330 340 350 360 RERGMTAYEM MLSESQERML IVIRPDRTDV ARAIFEKWEL DFAVIGHLTE TGHIVVRHQG 370 380 390 400 410 420 RVEADIPLDP LADQAPIYRR PTAPAPVPAP LGPLTDPVGI EQALIRLIGC PDLASRAWVW 430 440 450 460 470 480 NQYDSTVGGQ TVKRPGGADA AIVKIEDTSL GLALTTDCTP RYCRADARLG GAQAVAEAWR 490 500 510 520 530 540 NIVATGARPL AVTDNLNFGS PEKPEVMGQF VAAIEGMGEA CRALDFPVVS GNVSLYNETR 550 560 570 580 590 600 APDGSSVSIL PTPAIGGLGV LEDVAKAVGL AMPADCTLVL VGATRGEMGQ SLWLREIHGR 610 620 630 640 650 660 EDGPPPALDL AAERRNGDFV RGQIQDGHVV ACHDVADGGL LVTLAEMVMA GDVGCVLSAP 670 680 690 700 710 720 QSGIRPEAFW FGEDQSRYVV AVRDADAFTL AATGAGVETR VLGRSGGDGL TLPSGATIST 730 ARLNAVNSAF FPALMDR

References

[1]	"Gluconacetobacter diazotrophicus Pal5 complete genome." Bertalan M., Baldani I.J., Ferreira P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49037 / DSM 5601 / PAl5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM889285 Genomic DNA. Translation: CAP55903.1.
RefSeq	YP_001602205.1. NC_010125.1.
3D structure databases
ProteinModelPortal	A9HJG3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAP55903; CAP55903; GDI1960.
GeneID	5789312.
KEGG	gdi:GDI_1960.
PATRIC	22059468. VBIGluDia122154_1893.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01952.
OMA	WSEHCCY.
ProtClustDB	PRK01213.
Enzyme and pathway databases
BioCyc	GDIA272568:GJPS-1997-MONOMER.
UniPathway	UPA00074; UER00128.
Family and domain databases
HAMAP	MF_00420. PurL_2.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9HJG3_GLUDA

Accession

Primary (citable) accession number: A9HJG3

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)