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A9HI81

- UPPP_GLUDA

UniProt

A9HI81 - UPPP_GLUDA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciGDIA272568:GJPS-1825-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:GDI1791, Gdia_0020
    OrganismiGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
    Taxonomic identifieri272568 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter
    ProteomesiUP000000736: Chromosome, UP000001176: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Undecaprenyl-diphosphatasePRO_1000083979Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272568.GDI_1791.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3423HelicalUniRule annotationAdd
    BLAST
    Transmembranei49 – 6921HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei120 – 14021HelicalUniRule annotationAdd
    BLAST
    Transmembranei159 – 17921HelicalUniRule annotationAdd
    BLAST
    Transmembranei234 – 25421HelicalUniRule annotationAdd
    BLAST
    Transmembranei263 – 28321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiDSITFTQ.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9HI81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSRTMTLIQ AIVIAILQGA TELFPVSSLG HAVIVPALLG WAFDPHGEIF    50
    LPFLVMLHLG TAIALLVYFR NDWAAIFQGL RGRDGSQRQA ESIHILALLV 100
    VATIPAVIIG GLLEHWLRAL FGTARYAAIF LFLNGLLLLL TERMKSRQPV 150
    QGGYAIASLT YADAAIIGLW QCLAFLPGIS RSGATIIGAL FRGLNHEGAA 200
    RFSFLMAQPV IIAATVREAL HMRHVAIPPG QMQVATIGAM VAAVTALAST 250
    AFLMRYFHNH ERWALSPFGY YCVLAGAVSF FILGH 285
    Length:285
    Mass (Da):30,875
    Last modified:February 5, 2008 - v1
    Checksum:i28D2D8779312C7ED
    GO

    Sequence cautioni

    The sequence ACI49822.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM889285 Genomic DNA. Translation: CAP55734.1.
    CP001189 Genomic DNA. Translation: ACI49822.1. Different initiation.
    RefSeqiYP_001602036.1. NC_010125.1.
    YP_002274437.1. NC_011365.1.

    Genome annotation databases

    EnsemblBacteriaiACI49822; ACI49822; Gdia_0020.
    CAP55734; CAP55734; GDI1791.
    GeneIDi5790045.
    6973409.
    KEGGigdi:GDI_1791.
    gdj:Gdia_0020.
    PATRICi22048400. VBIGluDia203729_0021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM889285 Genomic DNA. Translation: CAP55734.1 .
    CP001189 Genomic DNA. Translation: ACI49822.1 . Different initiation.
    RefSeqi YP_001602036.1. NC_010125.1.
    YP_002274437.1. NC_011365.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272568.GDI_1791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI49822 ; ACI49822 ; Gdia_0020 .
    CAP55734 ; CAP55734 ; GDI1791 .
    GeneIDi 5790045.
    6973409.
    KEGGi gdi:GDI_1791.
    gdj:Gdia_0020.
    PATRICi 22048400. VBIGluDia203729_0021.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi DSITFTQ.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci GDIA272568:GJPS-1825-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the sugarcane nitrogen-fixing endophyte Gluconacetobacter diazotrophicus Pal5."
      Bertalan M., Albano R., de Padua V., Rouws L., Rojas C., Hemerly A., Teixeira K., Schwab S., Araujo J., Oliveira A., Franca L., Magalhaes V., Alqueres S., Cardoso A., Almeida W., Loureiro M.M., Nogueira E., Cidade D.
      , Oliveira D., Simao T., Macedo J., Valadao A., Dreschsel M., Freitas F., Vidal M., Guedes H., Rodrigues E., Meneses C., Brioso P., Pozzer L., Figueiredo D., Montano H., Junior J., de Souza Filho G., Martin Quintana Flores V., Ferreira B., Branco A., Gonzalez P., Guillobel H., Lemos M., Seibel L., Macedo J., Alves-Ferreira M., Sachetto-Martins G., Coelho A., Santos E., Amaral G., Neves A., Pacheco A.B., Carvalho D., Lery L., Bisch P., Rossle S.C., Urmenyi T., Rael Pereira A., Silva R., Rondinelli E., von Kruger W., Martins O., Baldani J.I., Ferreira P.C.
      BMC Genomics 10:450-450(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49037 / DSM 5601 / PAl5.
    2. "Two genome sequences of the same bacterial strain, Gluconacetobacter diazotrophicus PAl 5, suggest a new standard in genome sequence submission."
      Giongo A., Tyler H.L., Zipperer U.N., Triplett E.W.
      Stand. Genomic Sci. 2:309-317(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49037 / DSM 5601 / PAl5.

    Entry informationi

    Entry nameiUPPP_GLUDA
    AccessioniPrimary (citable) accession number: A9HI81
    Secondary accession number(s): B5ZJ44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3