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A9HI81 (UPPP_GLUDA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:GDI1791, Gdia_0020
OrganismGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP]
Taxonomic identifier272568 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence ACI49822.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000083979

Regions

Transmembrane12 – 3423Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane263 – 28321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9HI81 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 28D2D8779312C7ED

FASTA28530,875
        10         20         30         40         50         60 
MDSRTMTLIQ AIVIAILQGA TELFPVSSLG HAVIVPALLG WAFDPHGEIF LPFLVMLHLG 

        70         80         90        100        110        120 
TAIALLVYFR NDWAAIFQGL RGRDGSQRQA ESIHILALLV VATIPAVIIG GLLEHWLRAL 

       130        140        150        160        170        180 
FGTARYAAIF LFLNGLLLLL TERMKSRQPV QGGYAIASLT YADAAIIGLW QCLAFLPGIS 

       190        200        210        220        230        240 
RSGATIIGAL FRGLNHEGAA RFSFLMAQPV IIAATVREAL HMRHVAIPPG QMQVATIGAM 

       250        260        270        280 
VAAVTALAST AFLMRYFHNH ERWALSPFGY YCVLAGAVSF FILGH 

« Hide

References

[1]"Gluconacetobacter diazotrophicus Pal5 complete genome."
Bertalan M., Baldani I.J., Ferreira P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49037 / DSM 5601 / PAl5.
[2]"Complete sequence of chromosome of Gluconacetobacter diazotrophicus PAl 5."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Triplett E.W.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49037 / DSM 5601 / PAl5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM889285 Genomic DNA. Translation: CAP55734.1.
CP001189 Genomic DNA. Translation: ACI49822.1. Different initiation.
RefSeqYP_001602036.1. NC_010125.1.
YP_002274437.1. NC_011365.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272568.GDI_1791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI49822; ACI49822; Gdia_0020.
CAP55734; CAP55734; GDI1791.
GeneID5790045.
6973409.
KEGGgdi:GDI_1791.
gdj:Gdia_0020.
PATRIC22048400. VBIGluDia203729_0021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMALVPAWIG.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycGDIA272568:GJPS-1825-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_GLUDA
AccessionPrimary (citable) accession number: A9HI81
Secondary accession number(s): B5ZJ44
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families