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A9HHQ5

- A9HHQ5_GLUDA

UniProt

A9HHQ5 - A9HHQ5_GLUDA

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

purK

Organism
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: InterPro
  3. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciGDIA272568:GJPS-1756-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Name:purKImported
Ordered Locus Names:GDI1724Imported, Gdia_3505Imported
OrganismiGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)Imported
Taxonomic identifieri272568 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter
ProteomesiUP000000736: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272568.GDI_1724.

Structurei

3D structure databases

ProteinModelPortaliA9HHQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034029.
KOiK01589.
OMAiALQTWMP.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HHQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPFPEALP AGAVLGIVGG GQLGRMSAVA AAQLGFRAHI LTDEAEGPAA
60 70 80 90 100
QVAHAVTVGA YDDPDVLRRF ASSVDVVTFE FENISADGLE LLAGLCPVRP
110 120 130 140 150
SGRILRISQD RIAEKRFLAG AGIPLAPWAE IHTPQDLDTA IATLGLPFIL
160 170 180 190 200
KTTRLGYDGK GQHRVHAPDE ALPGFHALAP HPLVAEAMID FACEVSVMVA
210 220 230 240 250
RGLDGTAVTF DVTENRHRNG ILDISLAPAR VSADIAEQAR DIAMRVATAL
260 270 280 290 300
DLVGLLGVEM FVDRDGRVLV NEIAPRPHNS GHWTMDACPV DQFAMHVRAV
310 320 330 340 350
TGLPLPPAVR HSDAVMKNLV GPDDMALWPA ILATPGLLPH HYGKEEARPG
360 370 380
RKMGHVNVLF PHGGLPGEFG VNAALAPCLR NS
Length:382
Mass (Da):40,449
Last modified:February 5, 2008 - v1
Checksum:iADF6FE5E75ADC559
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001189 Genomic DNA. Translation: ACI53229.1.
AM889285 Genomic DNA. Translation: CAP55667.1.
RefSeqiYP_001601969.1. NC_010125.1.
YP_002277844.1. NC_011365.1.

Genome annotation databases

EnsemblBacteriaiACI53229; ACI53229; Gdia_3505.
CAP55667; CAP55667; GDI1724.
GeneIDi5789976.
6976957.
KEGGigdi:GDI_1724.
gdj:Gdia_3505.
PATRICi22055462. VBIGluDia203729_3487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001189 Genomic DNA. Translation: ACI53229.1 .
AM889285 Genomic DNA. Translation: CAP55667.1 .
RefSeqi YP_001601969.1. NC_010125.1.
YP_002277844.1. NC_011365.1.

3D structure databases

ProteinModelPortali A9HHQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272568.GDI_1724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI53229 ; ACI53229 ; Gdia_3505 .
CAP55667 ; CAP55667 ; GDI1724 .
GeneIDi 5789976.
6976957.
KEGGi gdi:GDI_1724.
gdj:Gdia_3505.
PATRICi 22055462. VBIGluDia203729_3487.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034029.
KOi K01589.
OMAi ALQTWMP.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci GDIA272568:GJPS-1756-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PAl 5Imported.
  2. "Complete genome sequence of the sugarcane nitrogen-fixing endophyte Gluconacetobacter diazotrophicus Pal5."
    Bertalan M., Albano R., de Padua V., Rouws L., Rojas C., Hemerly A., Teixeira K., Schwab S., Araujo J., Oliveira A., Franca L., Magalhaes V., Alqueres S., Cardoso A., Almeida W., Loureiro M.M., Nogueira E., Cidade D.
    , Oliveira D., Simao T., Macedo J., Valadao A., Dreschsel M., Freitas F., Vidal M., Guedes H., Rodrigues E., Meneses C., Brioso P., Pozzer L., Figueiredo D., Montano H., Junior J., de Souza Filho G., Martin Quintana Flores V., Ferreira B., Branco A., Gonzalez P., Guillobel H., Lemos M., Seibel L., Macedo J., Alves-Ferreira M., Sachetto-Martins G., Coelho A., Santos E., Amaral G., Neves A., Pacheco A.B., Carvalho D., Lery L., Bisch P., Rossle S.C., Urmenyi T., Rael Pereira A., Silva R., Rondinelli E., von Kruger W., Martins O., Baldani J.I., Ferreira P.C.
    BMC Genomics 10:450-450(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PAl 5Imported.
  3. "Two genome sequences of the same bacterial strain, Gluconacetobacter diazotrophicus PAl 5, suggest a new standard in genome sequence submission."
    Giongo A., Tyler H.L., Zipperer U.N., Triplett E.W.
    Stand. Genomic Sci. 2:309-317(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49037 / DSM 5601 / PAl5Imported and PAl 5Imported.

Entry informationi

Entry nameiA9HHQ5_GLUDA
AccessioniPrimary (citable) accession number: A9HHQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3