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Protein
Submitted name:

Histidinol dehydrogenase

Gene

hisD

Organism
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationSAAS annotationNote: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NADUniRule annotation
Binding sitei190 – 1901NADUniRule annotation
Binding sitei213 – 2131NADUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Metal bindingi258 – 2581ZincUniRule annotation
Binding sitei258 – 2581SubstrateUniRule annotation
Metal bindingi261 – 2611ZincUniRule annotation
Binding sitei261 – 2611SubstrateUniRule annotation
Active sitei326 – 3261Proton acceptorUniRule annotation
Active sitei327 – 3271Proton acceptorUniRule annotation
Binding sitei327 – 3271SubstrateUniRule annotation
Metal bindingi360 – 3601ZincUniRule annotation
Binding sitei360 – 3601SubstrateUniRule annotation
Binding sitei414 – 4141SubstrateUniRule annotation
Metal bindingi419 – 4191ZincUniRule annotation
Binding sitei419 – 4191SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciGDIA272568:GJPS-1464-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Submitted name:
Histidinol dehydrogenaseImported (EC:1.1.1.23Imported)
Submitted name:
Putative histidinol dehydrogenaseImported
Gene namesi
Name:hisDUniRule annotationImported
Ordered Locus Names:GDI1440Imported, Gdia_2140Imported
OrganismiGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)Imported
Taxonomic identifieri272568 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter
ProteomesiUP000000736 Componenti: Chromosome UP000001176 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272568.GDI_1440.

Structurei

3D structure databases

ProteinModelPortaliA9HFM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiIETFHNA.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HFM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLDTAQPD FRAAFARLLD DREGDTARVD APVAEILAAV RARGDEALCA
60 70 80 90 100
YTARFDRMPV TPDRLRITEA EIEAACARVP PDLLAALDVA ATRIEAFHRA
110 120 130 140 150
QMPADLRYTD ADGVDLGMRW TALDAVGLYV PGGTAAYPSS VLMNAMPARV
160 170 180 190 200
AGAARLAMCV PTPDGVLNPL VLAAARRAGV TEIYRVGGAQ AVAAMAYGTA
210 220 230 240 250
TIRPVDRVVG PGNAYVAEAK RQVFGRVGID SIAGPSEVVV VADSGTDPRI
260 270 280 290 300
VALDLLAQAE HDALAQSILI TQDATLADRV AEAVEAELRT LPRAAIAGAS
310 320 330 340 350
WGAHGAIITV RDLDEAASLI DAIAPEHLEL LLADPEPLFA RVRHAGAIFL
360 370 380 390 400
GRQCAEAIGD YVGGPNHVLP TSRTARFASG LSVFDFLKRT TFIGAGPDAL
410 420 430
RRIGPAAVAL ARAEGLDAHA LSVSARLDAV ARESDKA
Length:437
Mass (Da):45,822
Last modified:February 4, 2008 - v1
Checksum:i64E29B040A3D94A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001189 Genomic DNA. Translation: ACI51898.1.
AM889285 Genomic DNA. Translation: CAP55383.1.
RefSeqiWP_012224737.1. NC_011365.1.
YP_001601696.1. NC_010125.1.
YP_002276513.1. NC_011365.1.

Genome annotation databases

EnsemblBacteriaiACI51898; ACI51898; Gdia_2140.
CAP55383; CAP55383; GDI1440.
KEGGigdi:GDI_1440.
gdj:Gdia_2140.
PATRICi22052716. VBIGluDia203729_2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001189 Genomic DNA. Translation: ACI51898.1.
AM889285 Genomic DNA. Translation: CAP55383.1.
RefSeqiWP_012224737.1. NC_011365.1.
YP_001601696.1. NC_010125.1.
YP_002276513.1. NC_011365.1.

3D structure databases

ProteinModelPortaliA9HFM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272568.GDI_1440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI51898; ACI51898; Gdia_2140.
CAP55383; CAP55383; GDI1440.
KEGGigdi:GDI_1440.
gdj:Gdia_2140.
PATRICi22052716. VBIGluDia203729_2139.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiIETFHNA.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciGDIA272568:GJPS-1464-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PAl 5Imported.
  2. "Complete genome sequence of the sugarcane nitrogen-fixing endophyte Gluconacetobacter diazotrophicus Pal5."
    Bertalan M., Albano R., de Padua V., Rouws L., Rojas C., Hemerly A., Teixeira K., Schwab S., Araujo J., Oliveira A., Franca L., Magalhaes V., Alqueres S., Cardoso A., Almeida W., Loureiro M.M., Nogueira E., Cidade D.
    , Oliveira D., Simao T., Macedo J., Valadao A., Dreschsel M., Freitas F., Vidal M., Guedes H., Rodrigues E., Meneses C., Brioso P., Pozzer L., Figueiredo D., Montano H., Junior J., de Souza Filho G., Martin Quintana Flores V., Ferreira B., Branco A., Gonzalez P., Guillobel H., Lemos M., Seibel L., Macedo J., Alves-Ferreira M., Sachetto-Martins G., Coelho A., Santos E., Amaral G., Neves A., Pacheco A.B., Carvalho D., Lery L., Bisch P., Rossle S.C., Urmenyi T., Rael Pereira A., Silva R., Rondinelli E., von Kruger W., Martins O., Baldani J.I., Ferreira P.C.
    BMC Genomics 10:450-450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49037 / DSM 5601 / PAl5Imported and PAl 5Imported.
  3. "Two genome sequences of the same bacterial strain, Gluconacetobacter diazotrophicus PAl 5, suggest a new standard in genome sequence submission."
    Giongo A., Tyler H.L., Zipperer U.N., Triplett E.W.
    Stand. Genomic Sci. 2:309-317(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49037 / DSM 5601 / PAl5Imported and PAl 5Imported.

Entry informationi

Entry nameiA9HFM4_GLUDA
AccessioniPrimary (citable) accession number: A9HFM4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 4, 2008
Last sequence update: February 4, 2008
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.