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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi485MagnesiumUniRule annotation1
Metal bindingi491MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:GDI1371, Gdia_2075
OrganismiGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Taxonomic identifieri272568 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter
Proteomesi
  • UP000000736 Componenti: Chromosome
  • UP000001176 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296651 – 712Polyribonucleotide nucleotidyltransferaseAdd BLAST712

Interactioni

Protein-protein interaction databases

STRINGi272568.Gdia_2075.

Structurei

3D structure databases

ProteinModelPortaliA9HF35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 611KHUniRule annotationAdd BLAST60
Domaini621 – 689S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9HF35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNYYRKEIE WGGRPLVLET GKIARQADGA VVVTYGDTVV LCTAVGARSV
60 70 80 90 100
KPGQDFFPLT VNYQEKAFAA GKIPGGFFKR EGRPSEIEVL NSRLIDRPIR
110 120 130 140 150
PLFPENFRNE VQVVATVLSH DLENDPAIAA LIGCSAALTL SGIPFFGPVA
160 170 180 190 200
ACRVGYADGA YILNPTLPEM KESALDLVVA GTSEGVLMVE SEASELSEDV
210 220 230 240 250
MLGAVTFGHE AFQAVIDAII SLAEHAAKAP WDLAEPSAEE IALKQRIDTL
260 270 280 290 300
GRAAIAEAYQ ERVKQQRYKK VGAAKEAVLA ALATEGLDVT AAKPILKDLE
310 320 330 340 350
ADVVRSAVLD TGYRIDGRDL KTVRPIVSEV GILPRAHGSA LFTRGETQAL
360 370 380 390 400
VVATLGTAQD EQVIDALEGE YRTNFMLHYN FPPYSVGECG RMGSPGRREI
410 420 430 440 450
GHGKLAWRAI HPLLPGKDTF PYTMRIVSEI TESNGSSSMA TVCGTSLALM
460 470 480 490 500
DAGVPLKRPV AGIAMGLIKE DRGFAVLSDI LGDEDHLGDM DFKVAGTESG
510 520 530 540 550
ITALQMDIKI TSITPEIMKI ALGQARDGRL HILGEMSKAL TEGRSDVSST
560 570 580 590 600
APKITTISVP KEKIRDVIGQ GGKVIREIVE YSGAKIDIND DGTIMIAASS
610 620 630 640 650
EDQATRAIER IRGIVAEPEL GAIYTGKVVK TADFGAFVNF LGARDGLVHI
660 670 680 690 700
SELAQGRVAK TTDVVNQGDV VKVKVLGFDD RGKVKLSMRV VDQQTGADIT
710
ESVGERPGRP AR
Length:712
Mass (Da):76,309
Last modified:February 5, 2008 - v1
Checksum:iDB718FD99A59704E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889285 Genomic DNA. Translation: CAP55314.1.
CP001189 Genomic DNA. Translation: ACI51835.1.
RefSeqiWP_012224617.1. NC_011365.1.

Genome annotation databases

EnsemblBacteriaiACI51835; ACI51835; Gdia_2075.
CAP55314; CAP55314; GDI1371.
KEGGigdi:GDI1371.
gdj:Gdia_2075.
PATRICi22052576. VBIGluDia203729_2070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889285 Genomic DNA. Translation: CAP55314.1.
CP001189 Genomic DNA. Translation: ACI51835.1.
RefSeqiWP_012224617.1. NC_011365.1.

3D structure databases

ProteinModelPortaliA9HF35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272568.Gdia_2075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI51835; ACI51835; Gdia_2075.
CAP55314; CAP55314; GDI1371.
KEGGigdi:GDI1371.
gdj:Gdia_2075.
PATRICi22052576. VBIGluDia203729_2070.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_GLUDA
AccessioniPrimary (citable) accession number: A9HF35
Secondary accession number(s): B5ZDK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.