Reviewed, UniProtKB/Swiss-Prot A9H8D2 (AHPD_GLUDA)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	GDI0575, Gdia_1424

Organism

Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP]

Taxonomic identifier

272568 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359490
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9H8D2-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5AA4865EBA6EEB0F	FASTA	181	19,119
	10 20 30 40 50 60 MSIETLKERL PDYAKDLKLN LSSLANDITL SPQQLAGTFV ASAIASRNAD VTRAIVAEYE 70 80 90 100 110 120 SVLSPQALTA AKAAAAIMGL NNIYYRFVHM VEGDYAHMPA RLRMNVIGRP GVEKLDFELW 130 140 150 160 170 180 SLAVSAINGC GMCVESHEKV VREGGLSAEQ VQTAVRVAAT VHAVAATLDG AAALGDHPAA G

References

[1]

"Gluconacetobacter diazotrophicus Pal5 complete genome." Bertalan M., Baldani I.J., Ferreira P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete sequence of chromosome of Gluconacetobacter diazotrophicus PAl 5." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Triplett E.W. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM889285 Genomic DNA. Translation: CAP54518.1. CP001189 Genomic DNA. Translation: ACI51204.1.
RefSeq	YP_001600859.1. YP_002275819.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5792083. 6974832.
GenomeReviews	Gene locus GDI0575 in contig AM889285_GR. Gene locus Gdia_1424 in contig CP001189_GR.
KEGG	gdi:GDI0575. gdj:Gdia_1424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAMNNVY.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_GLUDA

Accession

Primary (citable) accession number: A9H8D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)