Reviewed, UniProtKB/Swiss-Prot A9H5B7 (IOLG_GLUDA)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	GDI0366, Gdia_2417

Organism

Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5) [Complete proteome] [HAMAP]

Taxonomic identifier

272568 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352569
Experimental info
	Sequence conflict	270	1	N → K in ACI52167. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	A9H5B7-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: B9104F42F458C6AC	FASTA	337	37,032
	10 20 30 40 50 60 MTLGIGVIGT GAIGQDHIRR VSRALSGGRI VALNDINADN ARRAAQEWAP DAVICDTARD 70 80 90 100 110 120 LVARPDVQAV MVTSWGGTHA EYVLDAIAAG KPVFCEKPLA TNAADCLRIM EAEMARGRRL 130 140 150 160 170 180 VQVGFNRRYD SGYLDLKAIL DNGTIGDVLM VHAMHRNQRV GPNYKTEMAI TDTLVHELDV 190 200 210 220 230 240 HRWLLDGEYV SAQVIFPRRT SKALPHMRDP QIALLETKRG IRIDVEIFVN CQYGYDIQCA 250 260 270 280 290 300 VVGELGQANL PDPPAVPVKT GETLSRHIMN DWKYRFIDAY DAEIQDFIDR ASTGSPAGPD 310 320 330 SWAGYAASVA ADACVRAQES GRIEPIEMIA KPAFYSR

References

[1]

"Gluconacetobacter diazotrophicus Pal5 complete genome." Bertalan M., Baldani I.J., Ferreira P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete sequence of chromosome of Gluconacetobacter diazotrophicus PAl 5." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Triplett E.W. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM889285 Genomic DNA. Translation: CAP54309.1. CP001189 Genomic DNA. Translation: ACI52167.1.
RefSeq	YP_001600653.1. YP_002276782.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5789781. 6975847.
GenomeReviews	Gene locus GDI0366 in contig AM889285_GR. Gene locus Gdia_2417 in contig CP001189_GR.
KEGG	gdi:GDI0366. gdj:Gdia_2417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_GLUDA

Accession

Primary (citable) accession number: A9H5B7
Secondary accession number(s): B5ZFL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)