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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGDIA272568:G1GTW-1669-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:GDI0050, Gdia_1640
OrganismiGluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)
Taxonomic identifieri272568 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconacetobacter
Proteomesi
  • UP000000736 Componenti: Chromosome
  • UP000001176 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000743231 – 466Glutamate--tRNA ligase 1Add BLAST466

Proteomic databases

PRIDEiA9GZS1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272568.Gdia_1640

Structurei

3D structure databases

ProteinModelPortaliA9GZS1
SMRiA9GZS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9GZS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRTRFAPS PTGLLHIGNA RAALFNFLYA RHHGGKFLLR IEDTDRERST
60 70 80 90 100
QQAVDVLFDG LAWMGITPDE EPVFQSTRQA RHAEIAHHLL AQGLAYRCYC
110 120 130 140 150
TPEELQQMRD QAAAEGRPPR YNGYWRDRDP SEAPAGAPYT VRIRAPREGE
160 170 180 190 200
TVIHDLVQGD VRVANAELDD MIILRGDGTP VYQLAVVVDD HDMDITHVIR
210 220 230 240 250
GDDHLTNTFR QAMIYRAMGW DLPAFAHLPL IHGPDGAKLS KRHGAQSVVE
260 270 280 290 300
FREMGYLPEA LNNYLLRLGW GHGDAEILSR DEQIQLFDLD GVGRSASRMD
310 320 330 340 350
YVKLQHLNGV WLRQADDARL TDDIVARLAD RPDVSVDEAV RARILALMPG
360 370 380 390 400
LKERAKTLVD LADSAAFLGR HVPLAFDAKA EKLLTPEARA MLGELARDLA
410 420 430 440 450
VIEPFDAPAI DVALRRFAEH HGHKLGQVAQ PLRAAMTGGA TSPGIDATLA
460
ALGRDEVMAR IGAVAR
Length:466
Mass (Da):51,608
Last modified:February 5, 2008 - v1
Checksum:iA178F3B9B205D606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889285 Genomic DNA Translation: CAP53993.1
CP001189 Genomic DNA Translation: ACI51417.1
RefSeqiWP_012222298.1, NC_011365.1

Genome annotation databases

EnsemblBacteriaiACI51417; ACI51417; Gdia_1640
CAP53993; CAP53993; GDI0050
KEGGigdi:GDI0050
gdj:Gdia_1640

Similar proteinsi

Entry informationi

Entry nameiSYE1_GLUDA
AccessioniPrimary (citable) accession number: A9GZS1
Secondary accession number(s): B5ZK54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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