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A9GWU7 (A9GWU7_SORC5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH3 EMBL CAN93977.1
Synonyms:fabH1 HAMAP MF_01815
Ordered Locus Names:sce3817
OrganismSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]
Taxonomic identifier448385 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Sorangiineae › Polyangiaceae › Sorangium

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region259 – 2635ACP-binding By similarity HAMAP MF_01815

Sites

Active site1171 By similarity HAMAP MF_01815
Active site2581 By similarity HAMAP MF_01815
Active site2881 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A9GWU7 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 1DE799D679FA6D01

FASTA33134,547
        10         20         30         40         50         60 
MSSPQPRSRI LGTGSYAPAR VVHNTDLEKI VDTSDSWISE RTGIRRRHIA AEGELTSDLA 

        70         80         90        100        110        120 
AAAGRSALDA AGLSAADLDM IIVGTISGDT PMPSCAVYVQ QKLGAQEIPA FDISAACAGF 

       130        140        150        160        170        180 
VYGLTIADQF IANGVARHVL VIGVELLSRI LNWKDRTTCV LFGDGAGAVV LGPASGDGRG 

       190        200        210        220        230        240 
IISTRIFSDG TLANSLVIPG GGTAEPLTPE GIEQSRNKVH MVGQDIFKVA VKNLSSASLI 

       250        260        270        280        290        300 
ALDTAGMAAG DLDWVVAHQA NLRIISQVAA RLSLPLERFV LNIEEYGNTS SASIPIALDE 

       310        320        330 
AVRDGRIKSG QNVLFCALGA GISWGASVIR M

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM746676 Genomic DNA. Translation: CAN93977.1.
RefSeqYP_001614457.1. NC_010162.1.

3D structure databases

ProteinModelPortalA9GWU7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9GWU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5814143.
GenomeReviewsGene locus sce3817 in contig AM746676_GR.
KEGGscl:sce3817.
PATRIC23665927. VBISorCel80414_4170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMATVAKMGY.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9GWU7_SORC5
AccessionPrimary (citable) accession number: A9GWU7
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info