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A9GVA4 (SYE_SORC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase
Short name=GluRS
Gene names
Name:gltX
Ordered Locus Names:sce0573
OrganismSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]
Taxonomic identifier448385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence CAN90730.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA aminoacylation for protein translation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

tRNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Glutamate--tRNA ligase
PRO_0000367769

Regions

Motif38 – 4811"HIGH" region
Motif316 – 3205"KMSKS" region

Sites

Binding site3191ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9GVA4 [UniParc].

Last modified March 24, 2009. Version 2.
Checksum: 73C98C4BCF1C7DD5

FASTA57164,413
        10         20         30         40         50         60 
MRLLFGDAAA SARRPEEYEA RYPRRALPKG AMVTRYAPSP TGFMHIGGIF VSLINKRLSL 

        70         80         90        100        110        120 
QSEGVFYLRL EDTDVKRAIP GALDTIVDSL ARFDLSPQEG VLRAPAKDGD ASSRGEFVQQ 

       130        140        150        160        170        180 
GSYGPYIQTE RVEIYRDYAI DLIRRGFAYP CFCTVEELDA IRQEQMALTV KPGVHGRWAK 

       190        200        210        220        230        240 
WRDAPLARVK EALAGGTPFV LRLRAPDDVS GRVEWKDGVK GVISMPVNDL DTILLKSDGI 

       250        260        270        280        290        300 
PTYHFAHAID DHLMRTTHVI RGDEWISSMP LHLQLFRTLG FRPVEYAHVP PIQKLDRVEE 

       310        320        330        340        350        360 
VDPETGETKV SDARRKLSKR KDPEANIAYY REIGVPETGT IEYLLNIANS AFEDWRKANP 

       370        380        390        400        410        420 
DKPYSAFPLK LNKLAPGGAL SDMVKLKSVS QAVVSRMSAE DVYAQGLDWA REHDKELAAL 

       430        440        450        460        470        480 
MERDPEYTKR ALGIERGGKK SNKRITTWPD LRPQLFFFYD ELYDRVDALD FPENVPEGDR 

       490        500        510        520        530        540 
QPLLRQMLDT FDPADSKEAW FEKIRQIAVA SGYAGEVKQY KASPESWKGH VGDVSMLLRV 

       550        560        570 
AVCGTRNSPD LTEVMAVLGE PRVRARIARF L 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM746676 Genomic DNA. Translation: CAN90730.1. Different initiation.
RefSeqYP_001611210.1. NC_010162.1.

3D structure databases

ProteinModelPortalA9GVA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING448385.sce0573.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN90730; CAN90730; sce0573.
GeneID5804613.
KEGGscl:sce0573.
PATRIC23658789. VBISorCel80414_0623.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000252720.
KOK01885.
OrthoDBEOG6DRPF7.

Enzyme and pathway databases

BioCycSCEL448385:GJ75-605-MONOMER.

Family and domain databases

Gene3D1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
InterProIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF48163. SSF48163. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYE_SORC5
AccessionPrimary (citable) accession number: A9GVA4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries