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A9GVA4

- SYE_SORC5

UniProt

A9GVA4 - SYE_SORC5

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).By similarity

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei319 – 3191ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-tRNA ligase activity Source: UniProtKB-EC
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSCEL448385:GJ75-605-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase (EC:6.1.1.17)
    Alternative name(s):
    Glutamyl-tRNA synthetase
    Short name:
    GluRS
    Gene namesi
    Name:gltX
    Ordered Locus Names:sce0573
    OrganismiSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
    Taxonomic identifieri448385 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium
    ProteomesiUP000002139: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571Glutamate--tRNA ligasePRO_0000367769Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi448385.sce0573.

    Structurei

    3D structure databases

    ProteinModelPortaliA9GVA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 4811"HIGH" regionAdd
    BLAST
    Motifi316 – 3205"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9GVA4-1 [UniParc]FASTAAdd to Basket

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    MRLLFGDAAA SARRPEEYEA RYPRRALPKG AMVTRYAPSP TGFMHIGGIF    50
    VSLINKRLSL QSEGVFYLRL EDTDVKRAIP GALDTIVDSL ARFDLSPQEG 100
    VLRAPAKDGD ASSRGEFVQQ GSYGPYIQTE RVEIYRDYAI DLIRRGFAYP 150
    CFCTVEELDA IRQEQMALTV KPGVHGRWAK WRDAPLARVK EALAGGTPFV 200
    LRLRAPDDVS GRVEWKDGVK GVISMPVNDL DTILLKSDGI PTYHFAHAID 250
    DHLMRTTHVI RGDEWISSMP LHLQLFRTLG FRPVEYAHVP PIQKLDRVEE 300
    VDPETGETKV SDARRKLSKR KDPEANIAYY REIGVPETGT IEYLLNIANS 350
    AFEDWRKANP DKPYSAFPLK LNKLAPGGAL SDMVKLKSVS QAVVSRMSAE 400
    DVYAQGLDWA REHDKELAAL MERDPEYTKR ALGIERGGKK SNKRITTWPD 450
    LRPQLFFFYD ELYDRVDALD FPENVPEGDR QPLLRQMLDT FDPADSKEAW 500
    FEKIRQIAVA SGYAGEVKQY KASPESWKGH VGDVSMLLRV AVCGTRNSPD 550
    LTEVMAVLGE PRVRARIARF L 571
    Length:571
    Mass (Da):64,413
    Last modified:March 24, 2009 - v2
    Checksum:i73C98C4BCF1C7DD5
    GO

    Sequence cautioni

    The sequence CAN90730.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM746676 Genomic DNA. Translation: CAN90730.1. Different initiation.
    RefSeqiYP_001611210.1. NC_010162.1.

    Genome annotation databases

    EnsemblBacteriaiCAN90730; CAN90730; sce0573.
    GeneIDi5804613.
    KEGGiscl:sce0573.
    PATRICi23658789. VBISorCel80414_0623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM746676 Genomic DNA. Translation: CAN90730.1 . Different initiation.
    RefSeqi YP_001611210.1. NC_010162.1.

    3D structure databases

    ProteinModelPortali A9GVA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 448385.sce0573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAN90730 ; CAN90730 ; sce0573 .
    GeneIDi 5804613.
    KEGGi scl:sce0573.
    PATRICi 23658789. VBISorCel80414_0623.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci SCEL448385:GJ75-605-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the myxobacterium Sorangium cellulosum."
      Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O., Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J., Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.
      , Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S., Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G., Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D., Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H., Puehler A., Mueller R.
      Nat. Biotechnol. 25:1281-1289(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: So ce56.

    Entry informationi

    Entry nameiSYE_SORC5
    AccessioniPrimary (citable) accession number: A9GVA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3